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Electrospinning of nanofibres with parallel line surface texture for improvement of nerve cell growth

Huang, Chen, Tang, Yanwei, Liu, Xin, Sutti, Alessandra, Ke, Qinfei, Mo, Xiumei, Wang, Xungai, Morsi, Yosry and Lin, Tong 2011, Electrospinning of nanofibres with parallel line surface texture for improvement of nerve cell growth, Soft matter, vol. 7, no. 22, pp. 10812-10817.

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Title Electrospinning of nanofibres with parallel line surface texture for improvement of nerve cell growth
Author(s) Huang, Chen
Tang, Yanwei
Liu, Xin
Sutti, Alessandra
Ke, Qinfei
Mo, Xiumei
Wang, Xungai
Morsi, Yosry
Lin, Tong
Journal name Soft matter
Volume number 7
Issue number 22
Start page 10812
End page 10817
Total pages 6
Publisher Royal Society of Chemistry
Place of publication Cambridge, U. K.
Publication date 2011
ISSN 1744-683X
1744-6848
Keyword(s) acetone
cell culture
cell growth
cellulose
cellulosic resins
electrospinning
esters
evaporation
fourier transform infrared spectroscopy
growth kinetics
molecular orientation
nanofibers
neurons
polystyrenes
solidification
solvents
textures
volatile fatty acids
Summary Nanofibres having a parallel line surface texture were electrospun from cellulose acetate butyrate solutions using a solvent mixture of acetone and N,N'-dimethylacetamide. The formation mechanism of the unusual surface feature was explored and attributed to the formation of voids on the jet surface at the early stage of electrospinning and subsequent elongation and solidification of the voids into a line surface structure. The fast evaporation of a highly volatile solvent, acetone, from the polymer solution was found to play a key role in the formation of surface voids, while the high viscosity of the residual solution after the solvent evaporation ensured the line surface to be maintained after the solidification. Based on this principle, nanofibres having a similar surface texture were also electrospun successfully from other polymers, such as cellulose acetate, polyvinylidene fluoride, poly(methyl methacrylate), polystyrene and poly(vinylidene fluoride-co-hexafluoropropene), either from the same or from different solvent systems. Polarized Fourier transform infrared spectroscopy was used to measure the polymer molecular orientation within nanofibres. Schwann cells were grown on both aligned and randomly oriented nanofibre mats. The parallel line surface texture assisted in the growth of Schwann cells especially at the early stage of cell culture regardless of the fibre orientation. In contrast, the molecular orientation within nanofibres showed little impact on the cell growth.
Language eng
Field of Research 091205 Functional Materials
Socio Economic Objective 860406 Synthetic Fibres, Yarns and Fabrics
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2011, The Royal Society of Chemistry
Persistent URL http://hdl.handle.net/10536/DRO/DU:30044364

Document type: Journal Article
Collections: Centre for Material and Fibre Innovation
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.