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Blockade of 5-HT2A receptors suppresses hyperthermic but not cardiovascular responses to psychosocial stress in rats

Beig, M. I., Baumert, M., Walker, F. R., Day, T. A. and Nalivaiko, E. 2009, Blockade of 5-HT2A receptors suppresses hyperthermic but not cardiovascular responses to psychosocial stress in rats, Neuroscience, vol. 159, no. 3, pp. 1185-1191, doi: 10.1016/j.neuroscience.2009.01.038.

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Title Blockade of 5-HT2A receptors suppresses hyperthermic but not cardiovascular responses to psychosocial stress in rats
Author(s) Beig, M. I.
Baumert, M.
Walker, F. R.
Day, T. A.
Nalivaiko, E.
Journal name Neuroscience
Volume number 159
Issue number 3
Start page 1185
End page 1191
Total pages 7
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2009-03-31
ISSN 0306-4522
1873-7544
Keyword(s) social defeat
heart rate
arterial pressure
core body temperature
5-HT
Summary The aim of this study was to determine whether 5-HT2A receptors mediate cardiovascular and thermogenic responses to acute psychological stresses. For this purpose, adult male Wistar hooded rats instrumented for telemetric recordings of either electrocardiogram (ECG) (n=12) or arterial pressure (n=12) were subjected, on different days, to four 15-min episodes of social defeat. Prior to stress, animals received s.c. injection of the selective 5-HT2A receptor antagonist SR-46349B (trans-4-((3Z)3-[(2-dimethylaminoethyl)oxyimino]-3-(2-fluorophenyl)propen-1-yl)-phenol, hemifumarate) (at doses of 0.3, 1.0 and 3.0 mg/kg) or vehicle. The drug had no effect on basal heart rate or heart rate variability indexes, arterial pressure, and core body temperature. Social defeat elicited significant and substantial tachycardic (347±7 to 500±7 bpm), pressor (77±4 to 97±4 mm Hg) and hyperthermic (37.0±0.3 to 38.5±0.1 °C) responses. Blockade of 5-HT2A receptors, at all doses of the antagonist, completely prevented stress-induced hyperthermia. In contrast, stress-induced cardiovascular responses were not affected by the blockade (except small reduction of tachycardia by the highest dose of the drug). We conclude that in rats, 5-HT2A receptors mediate stress-induced hyperthermic responses, but are not involved in the genesis of stress-induced rises in heart rate or arterial pressure, and do not participate in cardiovascular control at rest.
Language eng
DOI 10.1016/j.neuroscience.2009.01.038
Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2009, IBRO
Persistent URL http://hdl.handle.net/10536/DRO/DU:30044482

Document type: Journal Article
Collection: Faculty of Science, Engineering and Built Environment
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