The central nucleus of the amygdala ; a conduit for modulation of HPA axis responses to an immune challenge?

Buller, K. M., Crane, J. W. and Day, T. A. 2001, The central nucleus of the amygdala ; a conduit for modulation of HPA axis responses to an immune challenge?, Stress, vol. 4, no. 4, pp. 277-287, doi: 10.3109/10253890109014752.

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Title The central nucleus of the amygdala ; a conduit for modulation of HPA axis responses to an immune challenge?
Author(s) Buller, K. M.
Crane, J. W.
Day, T. A.
Journal name Stress
Volume number 4
Issue number 4
Start page 277
End page 287
Total pages 11
Publisher Informa Healthcare
Place of publication London, England
Publication date 2001
ISSN 1025-3890
Keyword(s) bed nucleus of the stria terminalis
central amygdala
HPA axis
interleukin- 1 p
neuroimmune interactions
nucleus tractus solitarius
Summary Physical stressors such as infection, inflammation and tissue injury elicit activation of the hypofhalamic-pituitary-adrenal (HPA) axis. This response has significant implications for both immune and central nervous system function. Investigations in rats into the neural substrates responsible for HPA axis activation to an immune challenge have predominantly utilized an experimental paradigm involving the acute administration of the pro-inflammatory cytokine interleukin-1 β (IL-1β). It is well recognized that medial parvocellular corticotrophin-releasing factor cells of the paraventricular nucleus (mPVN CRF) are critical in generating HPA axis responses to an immune challenge but little is known about how peripheral immune signals can activate and/or modulate the mPVN CRF cells. Studies that have examined the afferent control of the mPVN CRF cell response to systemic IL-1β have centred largely on the inputs from brainstem catecholamine cells. However, other regulatory neuronal populations also merit attention and one such region is a component of the limbic system, the central nucleus of the amygdala (CeA). A large number of CeA cells are recruited following systemic IL-lβ administration and there is a significant body of work indicating that the CeA can influence HPA axis function. However, the contribution of the CeA to HPA axis responses to an immune challenge is only just beginning to be addressed. This review examines three aspects of HPA axis control by systemic IL-lβ; (i) whether the CeA has a role in generating HPA axis responses to systemic IL-1 β, (ii) the identity of the neural connections between the CeA and mPVN CRF cells that might be important to HPA axis responses and (iii) the mechanisms by which systemic IL-lβ triggers the recruitment of CeA cells.
Language eng
DOI 10.3109/10253890109014752
Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2001, OPA
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Document type: Journal Article
Collection: Faculty of Science, Engineering and Built Environment
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