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A critical role for the parabrachial nucleus in generating central nervous system responses elicited by a systemic immune challenge

Buller, K. M., Allen, T., Wilson, L. D., Munro, F. and Day, T. A. 2004, A critical role for the parabrachial nucleus in generating central nervous system responses elicited by a systemic immune challenge, Journal of neuroimmunology, vol. 152, no. 1-2, pp. 20-32, doi: 10.1016/j.jneuroim.2004.03.013.

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Title A critical role for the parabrachial nucleus in generating central nervous system responses elicited by a systemic immune challenge
Author(s) Buller, K. M.
Allen, T.
Wilson, L. D.
Munro, F.
Day, T. A.
Journal name Journal of neuroimmunology
Volume number 152
Issue number 1-2
Start page 20
End page 32
Total pages 13
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2004-07
ISSN 0165-5728
1872-8421
0169-5088
Keyword(s) Bed nucleus of the stria terminalis
central amygdala
interleukin-1β
nucleus tractus solitarius
parabrachial nucleus
ventrolateral medulla
Summary Using Fos immunolabelling as a marker of neuronal activation, we investigated the role of the parabrachial nucleus in generating central neuronal responses to the systemic administration of the proinflammatory cytokine interleukin-1β (1 μg/kg, i.a.). Relative to intact animals, parabrachial nucleus lesions significantly reduced the number of Fos-positive cells observed in the central amygdala (CeA), the bed nucleus of the stria terminalis (BNST), and the ventrolateral medulla (VLM) after systemic interleukin-1β. In a subsequent experiment in which animals received parabrachial-directed deposits of a retrograde tracer, it was found that many neurons located in the nucleus tractus solitarius (NTS) and the VLM neurons were both retrogradely labelled and Fos-positive after interleukin-1β administration. These results suggest that the parabrachial nucleus plays a critical role in interleukin-1β-induced Fos expression in CeA, BNST and VLM neurons and that neurons of the NTS and VLM may serve to trigger or at least influence changes in parabrachial nucleus activity that follows systemic interleukin-1β administration.
Language eng
DOI 10.1016/j.jneuroim.2004.03.013
Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2004, Elsevier B.V.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30044487

Document type: Journal Article
Collection: Faculty of Science, Engineering and Built Environment
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