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Hypothalamic paraventricular nucleus neurons regulate medullary catecholamine cell responses to restraint stress

Dayas, Christopher V., Buller, Kathryn M. and Day, Trevor A. 2004, Hypothalamic paraventricular nucleus neurons regulate medullary catecholamine cell responses to restraint stress, Journal of comparative neurology, vol. 478, no. 1, pp. 22-34, doi: 10.1002/cne.20259.

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Title Hypothalamic paraventricular nucleus neurons regulate medullary catecholamine cell responses to restraint stress
Author(s) Dayas, Christopher V.
Buller, Kathryn M.
Day, Trevor A.
Journal name Journal of comparative neurology
Volume number 478
Issue number 1
Start page 22
End page 34
Total pages 13
Publisher Wiley
Place of publication London, England
Publication date 2004-10-04
ISSN 0021-9967
1096-9861
Keyword(s) amygdala
autonomic
Fos
nucleus tractus solitarius
restraint
ventrolateral medulla
Summary Both physical and psychological stressors recruit catecholamine cells (CA) located in the ventrolateral medulla (VLM) and the nucleus of the solitary tract (NTS). In the case of physical stressors, this effect is initiated by signals that first access the central nervous system at or below the level of the medulla. For psychological stressors, however, CA cell recruitment depends on higher structures within the neuraxis. Indeed, we have recently provided evidence of a pivotal role for the medial amygdala (MeA) in this regard, although such a role must involve a relay, as MeA neurons do not project directly to the medulla. However, some of the MeA neurons that respond to psychological stress have been found to project to the hypothalamic paraventricular nucleus (PVN), a structure that provides significant input to the medulla. To determine whether the PVN might regulate medullary CA cell responses to psychological stress, animals were prepared with unilateral injections of the neurotoxin ibotenic acid into the PVN (Experiment 1), or with unilateral injections of the retrograde tracer wheat germ agglutinin-gold (WGA-Au) into the CA cell columns of the VLM or NTS (Experiment 2). Seven days later, animals were subjected to a psychological stressor (restraint; 15 minutes), and their brains were subsequently processed for Fos plus appropriate cytoplasmic markers (Experiment 1), or Fos plus WGA-Au (Experiment 2). PVN lesions significantly suppressed the stress-related induction of Fos in both VLM and NTS CA cells, whereas tracer deposits in the VLM or NTS retrogradely labeled substantial numbers of PVN cells that were also Fos-positive after stress. Considered in concert with previous results, these data suggest that the activation of medullary CA cells in response to psychological stress may involve a critical input from the PVN.
Language eng
DOI 10.1002/cne.20259
Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2004, Wiley-Liss
Persistent URL http://hdl.handle.net/10536/DRO/DU:30044495

Document type: Journal Article
Collection: Faculty of Science, Engineering and Built Environment
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