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Medullary neurones regulate hypothalamic corticotropin-releasing factor cell responses to an emotional stressor

Dayas, C. V., Buller, K. M. and Day, T. A. 2001, Medullary neurones regulate hypothalamic corticotropin-releasing factor cell responses to an emotional stressor, Neuroscience, vol. 105, no. 3, pp. 707-719, doi: 10.1016/S0306-4522(01)00213-5.

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Title Medullary neurones regulate hypothalamic corticotropin-releasing factor cell responses to an emotional stressor
Author(s) Dayas, C. V.
Buller, K. M.
Day, T. A.
Journal name Neuroscience
Volume number 105
Issue number 3
Start page 707
End page 719
Total pages 13
Publisher Elsevier BV
Place of publication Amsterdam, The Netherlands
Publication date 2001-08-15
ISSN 0306-4522
1873-7544
Keyword(s) hypothalamic–pituitary–adrenal axis
noradrenergic cells
restraint
ventrolateral medulla
nucleus of the solitary tract
amygdala
Summary Hypothalamic–pituitary–adrenal axis activation is a hallmark of the stress response. In the case of physical stressors, there is considerable evidence that medullary catecholamine neurones are critical to the activation of the paraventricular nucleus corticotropin-releasing factor cells that constitute the apex of the hypothalamic–pituitary–adrenal axis. In contrast, it has been thought that hypothalamic–pituitary–adrenal axis responses to emotional stressors do not involve brainstem neurones. To investigate this issue we have mapped patterns of restraint-induced neuronal c-fos expression in intact animals and in animals prepared with either paraventricular nucleus-directed injections of a retrograde tracer, lesions of paraventricular nucleus catecholamine terminals, or lesions of the medulla corresponding to the A1 or A2 noradrenergic cell groups. Restraint-induced patterns of neuronal activation within the medulla of intact animals were very similar to those previously reported in response to physical stressors, including the fact that most stressor-responsive, paraventricular nucleus-projecting cells were certainly catecholaminergic and probably noradrenergic. Despite this, the destruction of paraventricular nucleus catecholamine terminals with 6-hydroxydopamine did not alter corticotropin-releasing factor cell responses to restraint. However, animals with ibotenic acid lesions encompassing either the A1 or A2 noradrenergic cell groups displayed significantly suppressed corticotropin-releasing factor cell responses to restraint. Notably, these medullary lesions also suppressed neuronal responses in the medial amygdala, an area that is now considered critical to hypothalamic–pituitary–adrenal axis responses to emotional stressors and that is also known to display a significant increase in noradrenaline turnover during restraint.

We conclude that medullary neurones influence corticotropin-releasing factor cell responses to emotional stressors via a multisynaptic pathway that may involve a noradrenergic input to the medial amygdala. These results overturn the idea that hypothalamic–pituitary–adrenal axis response to emotional stressors can occur independently of the brainstem.
Language eng
DOI 10.1016/S0306-4522(01)00213-5
Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2001, IBRO
Persistent URL http://hdl.handle.net/10536/DRO/DU:30044499

Document type: Journal Article
Collection: Faculty of Science, Engineering and Built Environment
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