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Opposing roles for medial and central amygdala in the initiation of noradrenergic cell responses to a psychological stressor

Dayas, C. V. and Day, T. A. 2002, Opposing roles for medial and central amygdala in the initiation of noradrenergic cell responses to a psychological stressor, European journal of neuroscience, vol. 15, no. 10, pp. 1712-1718, doi: 10.1046/j.1460-9568.2001.02011.x.

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Title Opposing roles for medial and central amygdala in the initiation of noradrenergic cell responses to a psychological stressor
Author(s) Dayas, C. V.
Day, T. A.
Journal name European journal of neuroscience
Volume number 15
Issue number 10
Start page 1712
End page 1718
Total pages 7
Publisher Wiley
Place of publication London, England
Publication date 2002-05
ISSN 1460-9568
Keyword(s) A1 cells
A2 cells
amygdala
restraint
stress
Summary Psychological stressors trigger the activation of medullary noradrenergic cells, an effect that has been shown to depend upon yet-to-be-identified structures located higher in the brain. To test whether the amygdala is important in this regard, we examined the effects of amygdala lesions on noradrenergic cell responses to restraint, and also looked at whether any amygdala cells that respond to restraint project directly to the medulla. Ibotenic acid lesions of the medial amygdala completely abolished restraint-induced Fos expression in A1 and A2 noradrenergic cells. In contrast, lesions of the central amygdala actually facilitated noradrenergic cell responses to restraint. Tracer deposits in the dorsomedial (but not ventrolateral) medulla retrogradely labelled many cells in the central nucleus of the amygdala, but none of these cells expressed Fos in response to restraint. These data suggest for the first time that the medial amygdala is critical to the activation of medullary noradrenergic cells by a psychological stressor whereas the central nucleus exerts an opposing, inhibitory influence upon noradrenergic cell recruitment. The initiation of noradrenergic cell responses by the medial amygdala does not involve a direct projection to the medulla. Accordingly, a relay through some other structure, such as the hypothalamic paraventricular nucleus, warrants careful consideration.
Language eng
DOI 10.1046/j.1460-9568.2001.02011.x
Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2002, Federation of European Neuroscience Societies
Persistent URL http://hdl.handle.net/10536/DRO/DU:30044502

Document type: Journal Article
Collection: Faculty of Science, Engineering and Built Environment
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