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Peripheral withdrawal recruits distinct central nuclei in morphine-dependent rats

Hamlin, A, Buller, K. M., Day, T. A. and Osborne, P. B. 2001, Peripheral withdrawal recruits distinct central nuclei in morphine-dependent rats, Neuropharmacology, vol. 41, no. 5, pp. 574-581, doi: 10.1016/S0028-3908(01)00101-0.

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Title Peripheral withdrawal recruits distinct central nuclei in morphine-dependent rats
Author(s) Hamlin, A
Buller, K. M.
Day, T. A.
Osborne, P. B.
Journal name Neuropharmacology
Volume number 41
Issue number 5
Start page 574
End page 581
Total pages 8
Publisher Pergamon
Place of publication Oxford, England
Publication date 2001-10
ISSN 0028-3908
Keyword(s) morphine dependence
substance withdrawal syndrome
naloxone methiodide
proto-oncogene proteins c-fos
Summary This study examined if brain pathways in morphine-dependent rats are activated by opioid withdrawal precipitated outside the central nervous system. Withdrawal precipitated with a peripherally acting quaternary opioid antagonist (naloxone methiodide) increased Fos expression but caused a more restricted pattern of neuronal activation than systemic withdrawal (precipitated with naloxone which enters the brain). There was no effect on locus coeruleus and significantly smaller increases in Fos neurons were produced in most other areas. However in the ventrolateral medulla (A1/C1 catecholamine neurons), nucleus of the solitary tract (A2/C2 catecholamine neurons), lateral parabrachial nucleus, supramamillary nucleus, bed nucleus of the stria terminalis, accumbens core and medial prefrontal cortex no differences in the withdrawal treatments were detected. We have shown that peripheral opioid withdrawal can affect central nervous system pathways.
Language eng
DOI 10.1016/S0028-3908(01)00101-0
Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C3.1 Non-refereed articles in a professional journal
Copyright notice ©2001, Elsevier Science
Persistent URL http://hdl.handle.net/10536/DRO/DU:30044503

Document type: Journal Article
Collection: Faculty of Science, Engineering and Built Environment
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