Peripheral withdrawal recruits distinct central nuclei in morphine-dependent rats Hamlin, A, Buller, K. M., Day, T. A. and Osborne, P. B. 2001, Peripheral withdrawal recruits distinct central nuclei in morphine-dependent rats, Neuropharmacology, vol. 41, no. 5, pp. 574-581, doi: 10.1016/S0028-3908(01)00101-0. Attached Files Name Description MIMEType Size Downloads Title Peripheral withdrawal recruits distinct central nuclei in morphine-dependent rats Author(s) Hamlin, A Buller, K. M. Day, T. A. Osborne, P. B. Journal name Neuropharmacology Volume number 41 Issue number 5 Start page 574 End page 581 Total pages 8 Publisher Pergamon Place of publication Oxford, England Publication date 2001-10 ISSN 0028-3908 Keyword(s) morphine dependence substance withdrawal syndrome naloxone methiodide proto-oncogene proteins c-fos Summary This study examined if brain pathways in morphine-dependent rats are activated by opioid withdrawal precipitated outside the central nervous system. Withdrawal precipitated with a peripherally acting quaternary opioid antagonist (naloxone methiodide) increased Fos expression but caused a more restricted pattern of neuronal activation than systemic withdrawal (precipitated with naloxone which enters the brain). There was no effect on locus coeruleus and significantly smaller increases in Fos neurons were produced in most other areas. However in the ventrolateral medulla (A1/C1 catecholamine neurons), nucleus of the solitary tract (A2/C2 catecholamine neurons), lateral parabrachial nucleus, supramamillary nucleus, bed nucleus of the stria terminalis, accumbens core and medial prefrontal cortex no differences in the withdrawal treatments were detected. We have shown that peripheral opioid withdrawal can affect central nervous system pathways. Language eng DOI 10.1016/S0028-3908(01)00101-0 Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences HERDC Research category C3.1 Non-refereed articles in a professional journal Copyright notice ©2001, Elsevier Science Persistent URL http://hdl.handle.net/10536/DRO/DU:30044503 Document type: Journal Article Collection: Faculty of Science, Engineering and Built Environment Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Thu, 19 Apr 2012, 10:27:06 EST Thu, 19 Apr 2012, 15:48:46 EST Thu, 19 Apr 2012, 15:49:50 EST Mon, 07 May 2012, 10:37:50 EST Filtered Full Citation counts:   Cited 18 times in TR Web of Science Cited 19 times in Scopus Search Google Scholar Access Statistics: 97 Abstract Views, 0 File Downloads  -  Detailed Statistics Created: Thu, 19 Apr 2012, 10:27:06 EST

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