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Repeated social defeat selectively increases ΔFosB expression and histone H3 acetylation in the infralimbic medial prefrontal cortex

Hinwood, Madeleine, Tynan, Ross J., Day, Trevor A. and Walker, F. Rohan 2011, Repeated social defeat selectively increases ΔFosB expression and histone H3 acetylation in the infralimbic medial prefrontal cortex, Cerebral cortex, vol. 21, no. 2, pp. 262-271, doi: 10.1093/cercor/bhq080.

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Title Repeated social defeat selectively increases ΔFosB expression and histone H3 acetylation in the infralimbic medial prefrontal cortex
Author(s) Hinwood, Madeleine
Tynan, Ross J.
Day, Trevor A.
Walker, F. Rohan
Journal name Cerebral cortex
Volume number 21
Issue number 2
Start page 262
End page 271
Total pages 10
Publisher Oxford University Press
Place of publication Oxford, England
Publication date 2011-02
ISSN 1047-3211
1460-2199
Keyword(s) chronic stress
infralimbic cortex
layer II/III
(medial) prefrontal cortex
social conflict
Summary Exposure to social stress has been linked to the development and maintenance of mood-related psychopathology; however, the underlying neurobiological changes remain uncertain. In this study, we examined numbers of ΔFosB-immunoreactive cells in the forebrains of rats subjected to 12 episodes of social defeat. This was achieved using the social conflict model whereby animals are introduced into the home cage of older males (“residents”) trained to attack and defeat all such “intruders”; importantly, controls were treated identically except that the resident was absent. Our results indicated that the only region in which ΔFosB-positive cells were found in significantly higher numbers in intruders than in controls was the infralimbic medial prefrontal cortex (mPFC). This same effect was not apparent using another psychological stressor, noise stress. Cells of the infralimbic mPFC also displayed evidence of chromatin remodeling. We found that exposure to repeated episodes of social defeat increased numbers of cells immunoreactive for histone H3 acetylation, but not for histone H3 phosphoacetylation, in the infralimbic mPFC. Collectively, these findings highlight the importance of the infralimbic mPFC in responding to social stress—a finding that provides insight into the possible neurobiological alterations associated with stress-induced psychiatric illness.
Language eng
DOI 10.1093/cercor/bhq080
Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2010, The Authors
Persistent URL http://hdl.handle.net/10536/DRO/DU:30044504

Document type: Journal Article
Collection: Faculty of Science, Engineering and Built Environment
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