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Role of catecholaminergic inputs to the medial prefrontal cortex in local and subcortical expression of Fos after psychological stress

Spencer, Sarah J. and Day, Trevor Anthony 2004, Role of catecholaminergic inputs to the medial prefrontal cortex in local and subcortical expression of Fos after psychological stress, Journal of neuroscience research, vol. 78, no. 2, pp. 279-288, doi: 10.1002/jnr.20242.

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Title Role of catecholaminergic inputs to the medial prefrontal cortex in local and subcortical expression of Fos after psychological stress
Author(s) Spencer, Sarah J.
Day, Trevor Anthony
Journal name Journal of neuroscience research
Volume number 78
Issue number 2
Start page 279
End page 288
Total pages 10
Publisher Wiley
Place of publication London, England
Publication date 2004-10-15
ISSN 0360-4012
Keyword(s) air puff
bed nucleus of the stria terminalis
medial parvocellular paraventricular hypothalamic corticotropin-releasing factor cells, paraventricular thalamic nucleus
Summary A wide variety of stressors elicit Fos expression in the medial prefrontal cortex (mPFC). No direct attempts, however, have been made to determine the role of the inputs that drive this response. We examined the effects of lesions of mPFC catecholamine terminals on local expression of Fos after exposure to air puff, a stimulus that in the rat acts as an acute psychological stressor. We also examined the effects of these lesions on Fos expression in a variety of subcortical neuronal populations implicated in the control of adrenocortical activation, one classic hallmark of the stress response. Lesions of the mPFC that were restricted to dopaminergic terminals significantly reduced numbers of Fos-immunoreactive (Fos-IR) cells seen in the mPFC after air puff, but had no significant effect on stress-induced Fos expression in the subcortical structures examined. Lesions of the mPFC that affected both dopaminergic and noradrenergic terminals also reduced numbers of Fos-IR cells observed in the mPFC after air puff. Additionally, these lesions resulted in a significant reduction in stress-induced Fos-IR in the ventral bed nucleus of the stria terminalis. These results demonstrate a role for catecholaminergic inputs to the mPFC, in the generation of both local and subcortical responses to psychological stress.
Language eng
DOI 10.1002/jnr.20242
Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2004, Wiley-Liss
Persistent URL http://hdl.handle.net/10536/DRO/DU:30044506

Document type: Journal Article
Collection: Faculty of Science, Engineering and Built Environment
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