Systemic apomorphine alters HPA axis responses to interleukin-1β adminstration but not sound stress

Buller, K. M., Crane, J. W., Spencer, S. J. and Day, T. A. 2003, Systemic apomorphine alters HPA axis responses to interleukin-1β adminstration but not sound stress, Psychoneuroendocrinology, vol. 28, no. 6, pp. 715-732, doi: 10.1016/S0306-4530(02)00065-3.

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Title Systemic apomorphine alters HPA axis responses to interleukin-1β adminstration but not sound stress
Author(s) Buller, K. M.
Crane, J. W.
Spencer, S. J.
Day, T. A.
Journal name Psychoneuroendocrinology
Volume number 28
Issue number 6
Start page 715
End page 732
Total pages 18
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2003-08
ISSN 0306-4530
Keyword(s) A2 noradrenergic cells
hypothalamic-pituitary-adrenal axis
interleukin-1β; Sound stress
Summary Apomorphine is a dopamine receptor agonist that was recently licensed for the treatment of erectile dysfunction. However, although sexual activity can be stressful, there has been little investigation into whether treatments for erectile dysfunction affect stress responses. We have examined whether a single dose of apomorphine, sufficient to produce penile erections (50 μg/kg, i.a.), can alter basal or stress-induced plasma ACTH levels, or activity of central pathways thought to control the hypothalamic-pituitary-adrenal axis in rats. An immune challenge (interleukin-1β, 1 μg/kg, i.a.) was used as a physical stressor while sound stress (100 dB white noise, 30 min) was used as a psychological stressor. Intravascular administration of apomorphine had no effect on basal ACTH levels but did substantially increase the number of Fos-positive amygdala and nucleus tractus solitarius catecholamine cells. Administration of apomorphine prior to immune challenge augmented the normal ACTH response to this stressor at 90 min and there was a corresponding increase in the number of Fos-positive paraventricular nucleus corticotropin-releasing factor cells, paraventricular nucleus oxytocin cells and nucleus tractus solitarius catecholamine cells. However, apomorphine treatment did not alter ACTH or Fos responses to sound stress. These data suggest that erection-inducing levels of apomorphine interfere with hypothalamic-pituitary-adrenal axis inhibitory feedback mechanisms in response to a physical stressor, but have no effect on the response to a psychological stressor. Consequently, it is likely that apomorphine acts on a hypothalamic-pituitary-adrenal axis control pathway that is unique to physical stressors. A candidate for this site of action is the nucleus tractus solitarius catecholamine cell population and, in particular, A2 noradrenergic neurons.
Language eng
DOI 10.1016/S0306-4530(02)00065-3
Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2003, Elsevier Science
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Document type: Journal Article
Collection: Faculty of Science, Engineering and Built Environment
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