Dielectrophoresis of micro/nano particles using curved microelectrodes Khoshmanesh, Khashayar, Tovar-Lopez, Francisco J., Baratchi, Sara, Zhang, Chen, Kayani, Aminuddin A., Chrimes, Adam F., Nahavandi, Saeid, Wlodkowic, Donald, Mitchell, Arnan and Kalantar-zadeh, Kourosh 2011, Dielectrophoresis of micro/nano particles using curved microelectrodes, in SPIE 2011 : Proceedings of SPIE - The International Society for Optical Engineering, SPIE, Bellingham, Wash., pp. 1-9. Attached Files Name Description MIMEType Size Downloads khoshmanesh-dielectrophoresisof-2011.pdf Published version application/pdf 5.15MB 259 Title Dielectrophoresis of micro/nano particles using curved microelectrodes Author(s) Khoshmanesh, Khashayar Tovar-Lopez, Francisco J. Baratchi, Sara Zhang, Chen Kayani, Aminuddin A. Chrimes, Adam F. Nahavandi, Saeid orcid.org/0000-0002-0360-5270 Wlodkowic, Donald Mitchell, Arnan Kalantar-zadeh, Kourosh Conference name Smart Nano-Micro Materials and Devices. Conference (2011 : Hawthorn, Vic.) Conference location Hawthorn, Vic. Conference dates 5-7 Dec. 2011 Title of proceedings SPIE 2011 : Proceedings of SPIE - The International Society for Optical Engineering Editor(s) Juodkazis, Saulius Gu, Min Publication date 2011 Conference series Smart Nano-Micro Materials and Devices Conference Start page 1 End page 9 Total pages 9 Publisher SPIE Place of publication Bellingham, Wash. Keyword(s) biomedical applications dead cells DEP force dielectrophoretic entrance region environmental scanning electron microscopy experimental analysis induced motions lab-on-a-chip systems micro fluidic system micro/nano particle microfluidic platforms morphological properties operating strategy polystyrene particle real time analysis strong electric fields trapping model tumour cells two parameter unique features Summary Dielectrophoresis, the induced motion of polarisable particles in non-homogenous electric field, has been proven as a versatile mechanism to transport, immobilise, sort and characterise micro/nano scale particle in microfluidic platforms. The performance of dielectrophoretic (DEP) systems depend on two parameters: the configuration of microelectrodes designed to produce the DEP force and the operating strategies devised to employ this force in such processes. This work summarises the unique features of curved microelectrodes for the DEP manipulation of target particles in microfluidic systems. The curved microelectrodes demonstrate exceptional capabilities including (i) creating strong electric fields over a large portion of their structure, (ii) minimising electro-thermal vortices and undesired disturbances at their tips, (iii) covering the entire width of the microchannel influencing all passing particles, and (iv) providing a large trapping area at their entrance region, as evidenced by extensive numerical and experimental analyses. These microelectrodes have been successfully applied for a variety of engineering and biomedical applications including (i) sorting and trapping model polystyrene particles based on their dimensions, (ii) patterning carbon nanotubes to trap low-conductive particles, (iii) sorting live and dead cells based on their dielectric properties, (iv) real-time analysis of drug-induced cell death, and (v) interfacing tumour cells with environmental scanning electron microscopy to study their morphological properties. The DEP systems based on curved microelectrodes have a great potential to be integrated with the future lab-on-a-chip systems. Notes Reproduced with the kind permission of the copyright owner. ISBN 9780819488459 ISSN 0277-786X Language eng Field of Research 091306 Microelectromechanical Systems (MEMS) Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences HERDC Research category E1 Full written paper - refereed Copyright notice ©2011, SPIE Free to Read? 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