Impact of resistance exercise training on interleukin-6 and JAK/STAT in young men

Trenerry, Marissa K., Della Gatta, Paul A., Larsen, Amy E., Garnham, Andrew P. and Cameron-Smith, David 2011, Impact of resistance exercise training on interleukin-6 and JAK/STAT in young men, Muscle & nerve, vol. 43, no. 3, pp. 385-392, doi: 10.1002/mus.21875.

Attached Files
Name Description MIMEType Size Downloads

Title Impact of resistance exercise training on interleukin-6 and JAK/STAT in young men
Author(s) Trenerry, Marissa K.
Della Gatta, Paul A.ORCID iD for Della Gatta, Paul A.
Larsen, Amy E.
Garnham, Andrew P.
Cameron-Smith, David
Journal name Muscle & nerve
Volume number 43
Issue number 3
Start page 385
End page 392
Total pages 8
Publisher John Wiley & Sons, Inc.
Place of publication New York, N. Y.
Publication date 2011-03
ISSN 0148-639X
Keyword(s) exercise
Summary The JAK/STAT signaling pathway is essential for myogenic regeneration and is regulated by a diverse range of ligands, including interleukin-6 (IL-6) and platelet-derived growth factor-BB (PDGF-BB). Our aim was to evaluate the responsiveness of IL-6 and PDGF-BB to intense exercise, along with STAT3 activation, before and after 12 weeks of resistance training. In young men, IL-6 and PDGF-BB protein concentrations were quantified in biopsied muscle and increased at 3 h post-exercise (17.5-fold and 3-fold, respectively). The response was unaltered by 12 weeks of training. Similarly, STAT3 phosphorylation was elevated post-exercise (12.5-fold), irrespective of training status, as was the expression of downstream targets c-MYC (8-fold), c-FOS (4.5-fold), and SOCS3 (2.3-fold). Thus, intense exercise transiently increases IL-6 and PDGF-BB proteins, and STAT3 phosphorylation is increased. These responses are preserved after intense exercise. This suggests they are not modified by training and may be an essential component of the adaptive responses to intense exercise.
Language eng
DOI 10.1002/mus.21875
Field of Research 060103 Cell Development, Proliferation and Death
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2010, Wiley Periodicals
Persistent URL

Connect to link resolver
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 19 times in TR Web of Science
Scopus Citation Count Cited 22 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 447 Abstract Views, 3 File Downloads  -  Detailed Statistics
Created: Tue, 01 May 2012, 11:51:48 EST by Jane Moschetti

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact