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Whey protein ingestion activates mTOR-dependent signalling after resistance exercise in young men : a double-blinded randomized controlled trial

Farnfield, Michelle M., Carey, Kate A., Gran, Petra, Trenerry, Marissa K. and Cameron-Smith, David 2009, Whey protein ingestion activates mTOR-dependent signalling after resistance exercise in young men : a double-blinded randomized controlled trial, Nutrients, vol. 1, no. 2, pp. 263-275.

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Title Whey protein ingestion activates mTOR-dependent signalling after resistance exercise in young men : a double-blinded randomized controlled trial
Author(s) Farnfield, Michelle M.
Carey, Kate A.
Gran, Petra
Trenerry, Marissa K.
Cameron-Smith, David
Journal name Nutrients
Volume number 1
Issue number 2
Start page 263
End page 275
Total pages 13
Publisher M D P I
Place of publication Basel, Switzerland
Publication date 2009-12
ISSN 2072-6643
Keyword(s) leucine
BCAA
p70S6K
4E-BP1
resistance exercise
Summary The effect of resistance exercise with the ingestion of supplementary protein on the activation of the mTOR cascade, in human skeletal muscle has not been fully elucidated. In this study, the impact of a single bout of resistance exercise, immediately followed by a single dose of whey protein isolate (WPI) or placebo supplement, on the activation of mTOR signalling was analyzed. Young untrained men completed a maximal single-legged knee extension exercise bout and were randomized to ingest either WPI supplement (n = 7) or the placebo (n = 7). Muscle biopsies were taken from the vastus lateralis before, and 2, 4 and 24 hr post-exercise. WPI or placebo ingestion consumed immediately post-exercise had no impact on the phosphorylation of Akt (Ser473). However, WPI significantly enhanced phosphorylation of mTOR (Ser2448), 4E-BP1 (Thr37/46) and p70S6K (Thr389) at 2 hr post-exercise. This study demonstrates that a single dose of WPI, when consumed in modest quantities, taken immediately after resistance exercise elicits an acute and transient activation of translation initiation within the exercised skeletal muscle.
Language eng
Field of Research 060103 Cell Development, Proliferation and Death
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2009, MDPI
Persistent URL http://hdl.handle.net/10536/DRO/DU:30044951

Document type: Journal Article
Collections: School of Exercise and Nutrition Sciences
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.