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Glucose production during strenuous exercise in humans : role of epinephrine

Howlett, Kirsten, Febbraio, Mark and Hargreaves, Mark 1999, Glucose production during strenuous exercise in humans : role of epinephrine, American journal of physiology, vol. 276, no. 6, pp. E1130-E1135.

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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Title Glucose production during strenuous exercise in humans : role of epinephrine
Author(s) Howlett, Kirsten
Febbraio, Mark
Hargreaves, Mark
Journal name American journal of physiology
Volume number 276
Issue number 6
Start page E1130
End page E1135
Total pages 6
Publisher American Physiological Society
Place of publication Bethesda, Md.
Publication date 1999-06
ISSN 0193-1849
Keyword(s) liver
catecholamines
glucose kinetics
Summary The increase in hepatic glucose production (HGP) that occurs during intense exercise is accompanied by a simultaneous increase in epinephrine, which suggests that epinephrine may be important in regulating HGP. To further investigate this, six trained men were studied twice. The first trial [control (Con)] consisted of 20 min of cycling at 40 ± 1% peak oxygen uptake (V˙o 2 peak) followed by 20 min at 80 ± 2%V˙o 2 peak. During the second trial [epinephrine (Epi)], subjects exercised for 40 min at 41 ± 2%V˙o 2 peak. Epinephrine was infused during the latter 20 min of exercise and resulted in plasma levels similar to those measured during intense exercise in Con. Glucose kinetics were measured using a primed, continuous infusion of [3-3H]glucose. HGP was similar at rest (Con, 11.0 ± 0.5 and Epi, 11.1 ± 0.5 μmol ⋅ kg−1 ⋅ min−1). In Con, HGP increased (P < 0.05) during exercise to 41.0 ± 5.2 μmol ⋅ kg−1 ⋅ min−1at 40 min. In Epi, HGP was similar to Con during the first 20 min of exercise. Epinephrine infusion increased (P < 0.05) HGP to 24.0 ± 2.5 μmol ⋅ kg−1 ⋅ min−1at 40 min, although this was less (P< 0.05) than the value in Con. The results suggest that epinephrine can increase HGP during exercise in trained men; however, epinephrine during intense exercise cannot fully account for the rise in HGP. Other glucoregulatory factors must contribute to the increase in HGP during intense exercise.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©1999, American Physiological Society
Persistent URL http://hdl.handle.net/10536/DRO/DU:30045226
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