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Effect of adrenaline on glucose kinetics during exercise in adrenalectomised humans Howlett, K, Galbo, H., Lorentsen, J., Bergeron, R., Zimmerman-Belsing, T., Bulow, J., Feldt-Rasmussen, U. and Kjaer, M. 1999, Effect of adrenaline on glucose kinetics during exercise in adrenalectomised humans, Journal of physiology, vol. 519, no. 3, pp. 911-921. Attached Files Name Description MIMEType Size Downloads Title Effect of adrenaline on glucose kinetics during exercise in adrenalectomised humans Author(s) Howlett, K Galbo, H. Lorentsen, J. Bergeron, R. Zimmerman-Belsing, T. Bulow, J. Feldt-Rasmussen, U. Kjaer, M. Journal name Journal of physiology Volume number 519 Issue number 3 Start page 911 End page 921 Total pages 11 Publisher Wiley-Blackwell Publishing Place of publication Oxford, England Publication date 1999-09 ISSN 0022-3751 1469-7793 Keyword(s) adrenalectomy blood glucose epinephrine exercise fatty acids nonesterified female humans kinetics lactic acid male middle aged Summary 1. The role of adrenaline in regulating hepatic glucose production and muscle glucose uptake during exercise was examined in six adrenaline deficient, bilaterally adrenalectomised humans. Six sex and age matched healthy individuals served as controls (CON). 2. Adrenalectomised subjects cycled for 45 min at 68 ± 1% maximum pulmonary Oμ uptake (VOμ,max), followed by 15 min at 84 ± 2% VOμ,max without (−ADR) or with (+ADR) adrenaline infusion, which elevated plasma adrenaline levels (45 min, 4·49 ± 0·69 nmol l¢; 60 min, 12·41 ± 1·80 nmol l¢; means ± s.e.m.). Glucose kinetics were measured using [3_ÅH]glucose. 3. Euglycaemia was maintained during exercise in CON and −ADR, whilst in +ADR plasma glucose was elevated. The exercise induced increase in hepatic glucose production was similar in +ADR and −ADR; however, adrenaline infusion augmented the rise in hepatic glucose production early in exercise. Glucose uptake increased during exercise in +ADR and −ADR, but was lower and metabolic clearance rate was reduced in +ADR. 4. During exercise noradrenaline and glucagon concentrations increased, and insulin and cortisol concentrations decreased, but plasma levels were similar between trials. Adrenaline infusion suppressed growth hormone and elevated plasma free fatty acids, glycerol and lactate. Alanine and â_hydroxybutyrate levels were similar between trials. 5. The results demonstrate that glucose homeostasis was maintained during exercise in adrenalectomised subjects. Adrenaline does not appear to play a major role in matching hepatic glucose production to the increase in glucose clearance. In contrast, adrenaline infusion results in a mismatch by simultaneously enhancing hepatic glucose production and inhibiting glucose clearance. Language eng Field of Research 119999 Medical and Health Sciences not elsewhere classified Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences HERDC Research category C1.1 Refereed article in a scholarly journal Persistent URL http://hdl.handle.net/10536/DRO/DU:30045227 Document type: Journal Article Collection: School of Exercise and Nutrition Sciences Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Mon, 14 May 2012, 13:21:15 EST Mon, 16 Jul 2012, 15:01:43 EST Mon, 16 Jul 2012, 15:03:22 EST Fri, 13 Jun 2014, 14:04:52 EST Filtered Full Citation counts:   Cited 30 times in TR Web of Science Search Google Scholar Access Statistics: 41 Abstract Views, 1 File Downloads  -  Detailed Statistics Created: Mon, 14 May 2012, 13:21:15 EST

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