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Effect of adrenaline on glucose kinetics during exercise in adrenalectomised humans

Howlett, K, Galbo, H., Lorentsen, J., Bergeron, R., Zimmerman-Belsing, T., Bulow, J., Feldt-Rasmussen, U. and Kjaer, M. 1999, Effect of adrenaline on glucose kinetics during exercise in adrenalectomised humans, Journal of physiology, vol. 519, no. 3, pp. 911-921.

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Title Effect of adrenaline on glucose kinetics during exercise in adrenalectomised humans
Author(s) Howlett, K
Galbo, H.
Lorentsen, J.
Bergeron, R.
Zimmerman-Belsing, T.
Bulow, J.
Feldt-Rasmussen, U.
Kjaer, M.
Journal name Journal of physiology
Volume number 519
Issue number 3
Start page 911
End page 921
Total pages 11
Publisher Wiley-Blackwell Publishing
Place of publication Oxford, England
Publication date 1999-09
ISSN 0022-3751
1469-7793
Keyword(s) adrenalectomy
blood glucose
epinephrine
exercise
fatty acids
nonesterified
female
humans
kinetics
lactic acid
male
middle aged
Summary 1. The role of adrenaline in regulating hepatic glucose production and muscle glucose uptake during exercise was examined in six adrenaline deficient, bilaterally adrenalectomised humans. Six sex and age matched healthy individuals served as controls (CON).

2. Adrenalectomised subjects cycled for 45 min at 68 ± 1% maximum pulmonary Oμ uptake (VOμ,max), followed by 15 min at 84 ± 2% VOμ,max without (−ADR) or with (+ADR) adrenaline infusion, which elevated plasma adrenaline levels (45 min, 4·49 ± 0·69 nmol l¢; 60 min, 12·41 ± 1·80 nmol l¢; means ± s.e.m.). Glucose kinetics were measured using [3_ÅH]glucose.

3. Euglycaemia was maintained during exercise in CON and −ADR, whilst in +ADR plasma glucose was elevated. The exercise induced increase in hepatic glucose production was similar in +ADR and −ADR; however, adrenaline infusion augmented the rise in hepatic glucose production early in exercise. Glucose uptake increased during exercise in +ADR and −ADR, but was lower and metabolic clearance rate was reduced in +ADR.

4. During exercise noradrenaline and glucagon concentrations increased, and insulin and cortisol concentrations decreased, but plasma levels were similar between trials. Adrenaline infusion suppressed growth hormone and elevated plasma free fatty acids, glycerol and lactate. Alanine and â_hydroxybutyrate levels were similar between trials.

5. The results demonstrate that glucose homeostasis was maintained during exercise in adrenalectomised subjects. Adrenaline does not appear to play a major role in matching hepatic glucose production to the increase in glucose clearance. In contrast, adrenaline infusion results in a mismatch by simultaneously enhancing hepatic glucose production and inhibiting glucose clearance.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30045227

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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