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Effect of increased blood glucose availability on glucose kinetics during exercise

Howlett, Kirsten, Angus, Damien, Proietto, Joseph and Hargreaves, Mark 1998, Effect of increased blood glucose availability on glucose kinetics during exercise, Journal of applied physiology, vol. 84, no. 4, pp. 1413-1417.

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Title Effect of increased blood glucose availability on glucose kinetics during exercise
Author(s) Howlett, Kirsten
Angus, Damien
Proietto, Joseph
Hargreaves, Mark
Journal name Journal of applied physiology
Volume number 84
Issue number 4
Start page 1413
End page 1417
Total pages 5
Publisher American Physiological Society
Place of publication Bethesda, Md.
Publication date 1998-04
ISSN 8750-7587
1522-1601
Keyword(s) liver glucose output
muscle glucose uptake
hyperglycemia
Summary This study examined the effect of increased blood glucose availability on glucose kinetics during exercise. Five trained men cycled for 40 min at 77 ± 1% peak oxygen uptake on two occasions. During the second trial (Glu), glucose was infused at a rate equal to the average hepatic glucose production (HGP) measured during exercise in the control trial (Con). Glucose kinetics were measured by a primed continuous infusion ofd-[3-3H]glucose. Plasma glucose increased during exercise in both trials and was significantly higher in Glu. HGP was similar at rest (Con, 11.4 ± 1.2; Glu, 10.6 ± 0.6 μmol ⋅ kg−1 ⋅ min−1). After 40 min of exercise, HGP reached a peak of 40.2 ± 5.5 μmol ⋅ kg−1 ⋅ min−1in Con; however, in Glu, there was complete inhibition of the increase in HGP during exercise that never rose above the preexercise level. The rate of glucose disappearance was greater (P < 0.05) during the last 15 min of exercise in Glu. These results indicate that an increase in glucose availability inhibits the rise in HGP during exercise, suggesting that metabolic feedback signals can override feed-forward activation of HGP during strenuous exercise.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©1998, American Physiological Society
Persistent URL http://hdl.handle.net/10536/DRO/DU:30045228

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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