Effect of heat stress on glucose kinetics during exercise

Hargreaves, Mark, Angus, Damien, Howlett, Kirsten, Marmy Conus, Nelly and Febbraio, Mark 1996, Effect of heat stress on glucose kinetics during exercise, Journal of applied physiology, vol. 81, no. 4, pp. 1594-1597.

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Title Effect of heat stress on glucose kinetics during exercise
Author(s) Hargreaves, Mark
Angus, Damien
Howlett, Kirsten
Marmy Conus, Nelly
Febbraio, Mark
Journal name Journal of applied physiology
Volume number 81
Issue number 4
Start page 1594
End page 1597
Total pages 4
Publisher American Physiological Society
Place of publication Bethesda, Md.
Publication date 1996-10
ISSN 8750-7587
1522-1601
Keyword(s) hyperglycemia
catecholamines
hyperthermia
Summary To identify the mechanism underlying the exaggerated hyperglycemia during exercise in the heat, six trained men were studied during 40 min of cycling exercise at a workload requiring 65% peak pulmonary oxygen uptake (V˙o 2 peak) on two occasions at least 1 wk apart. On one occasion, the ambient temperature was 20°C [control (Con)], whereas on the other, it was 40°C [high temperature (HT)]. Rates of glucose appearance and disappearance were measured by using a primed continuous infusion of [6,6-2H]glucose. No differences in oxygen uptake during exercise were observed between trials. After 40 min of exercise, heart rate, rectal temperature, respiratory exchange ratio, and plasma lactate were all higher in HT compared with Con (P < 0.05). Plasma glucose levels were similar at rest (Con, 4.54 ± 0.19 mmol/l; HT, 4.81 ± 0.19 mmol/l) but increased to a greater extent during exercise in HT (6.96 ± 0.16) compared with Con (5.45 ± 0.18;P < 0.05). This was the result of a higher glucose rate of appearance in HT during the last 30 min of exercise. In contrast, the glucose rate of disappearance and metabolic clearance rate were not different at any time point during exercise. Plasma catecholamines were higher after 10 and 40 min of exercise in HT compared with Con (P < 0.05), whereas plasma glucagon, cortisol, and growth hormone were higher in HT after 40 min. These results indicate that the hyperglycemia observed during exercise in the heat is caused by an increase in liver glucose output without any change in whole body glucose utilization.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©1996, American Physiological Society
Persistent URL http://hdl.handle.net/10536/DRO/DU:30045229

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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