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Akt signalling through GSK-3beta, mTOR and Foxo1 is involved in human skeletal muscle hypertrophy and atrophy

Leger, Bertrand, Cartoni, Romain, Praz, Manu, Lamon, Severine, Deriaz, Olivier, Crettenand, Antoinette, Gobelet, Charles, Rohmer, Paul, Konzelmann, Michel, Luthi, Francois and Russell, Aaron P. 2006, Akt signalling through GSK-3beta, mTOR and Foxo1 is involved in human skeletal muscle hypertrophy and atrophy, Journal of physiology, vol. 576, no. 3, pp. 923-933, doi: 10.1113/jphysiol.2006.116715.

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Title Akt signalling through GSK-3beta, mTOR and Foxo1 is involved in human skeletal muscle hypertrophy and atrophy
Author(s) Leger, Bertrand
Cartoni, Romain
Praz, Manu
Lamon, SeverineORCID iD for Lamon, Severine orcid.org/0000-0002-3271-6551
Deriaz, Olivier
Crettenand, Antoinette
Gobelet, Charles
Rohmer, Paul
Konzelmann, Michel
Luthi, Francois
Russell, Aaron P.ORCID iD for Russell, Aaron P. orcid.org/0000-0002-7323-9501
Journal name Journal of physiology
Volume number 576
Issue number 3
Start page 923
End page 933
Total pages 11
Publisher Wiley - Blackwell
Place of publication West Sussex, England
Publication date 2006-11
ISSN 0022-3751
1469-7793
Summary Skeletal muscle size is tightly regulated by the synergy between anabolic and catabolic signalling pathways which, in humans, have not been well characterized. Akt has been suggested to play a pivotal role in the regulation of skeletal muscle hypertrophy and atrophy in rodents and cells. Here we measured the amount of phospho-Akt and several of its downstream anabolic targets (glycogen synthase kinase-3β (GSK-3β), mTOR, p70s6k and 4E-BP1) and catabolic targets (Foxo1, Foxo3, atrogin-1 and MuRF1). All measurements were performed in human quadriceps muscle biopsies taken after 8 weeks of both hypertrophy-stimulating resistance training and atrophy-stimulating de-training. Following resistance training a muscle hypertrophy (∼10%) and an increase in phospho-Akt, phospho-GSK-3β and phospho-mTOR protein content were observed. This was paralleled by a decrease in Foxo1 nuclear protein content. Following the de-training period a muscle atrophy (5%), relative to the post-training muscle size, a decrease in phospho-Akt and GSK-3β and an increase in Foxo1 were observed. Atrogin-1 and MuRF1 increased after the hypertrophy and decreased after the atrophy phases. We demonstrate, for the first time in human skeletal muscle, that the regulation of Akt and its downstream signalling pathways GSK-3β, mTOR and Foxo1 are associated with both the skeletal muscle hypertrophy and atrophy processes.
Language eng
DOI 10.1113/jphysiol.2006.116715
Field of Research 060111 Signal Transduction
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30045289

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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