Meta-analytic review of neurocognition in bipolar II disorder

Bora, E., Yucel, M., Pantelis, C. and Berk, M. 2011, Meta-analytic review of neurocognition in bipolar II disorder, Acta psychiatrica scandinavica, vol. 123, no. 3, pp. 165-174.

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Title Meta-analytic review of neurocognition in bipolar II disorder
Alternative title Review : Meta-analytic review of neurocognition in bipolar II disorder
Author(s) Bora, E.
Yucel, M.
Pantelis, C.
Berk, M.
Journal name Acta psychiatrica scandinavica
Volume number 123
Issue number 3
Start page 165
End page 174
Total pages 10
Publisher Wiley-Blackwell Publishing, Inc.
Place of publication Malden Mass.
Publication date 2011-03
ISSN 0001-690X
Keyword(s) bipolar disorder
cognition
neuropsychology
meta-analysis
Summary Objective: The clinical distinction between bipolar II disorder (BD II) and bipolar I disorder (BD I) is not clear-cut. Cognitive functioning offers the potential to explore objective markers to help delineate this boundary. To examine this issue, we conducted a quantitative review of the cognitive profile of clinically stable patients with BD II in comparison with both patients with BD I and healthy controls.
Method: Meta-analytical methods were used to compare cognitive functioning of BD II disorder with both BD I disorder and healthy controls.
Results: Individuals with BD II were less impaired than those with BD I on verbal memory. There were also small but significant difference in
visual memory and semantic fluency. There were no significant differences in global cognition or in other cognitive domains. Patients with BD II performed poorer than controls in all cognitive domains.
Conclusion: Our findings suggest that with the exception of memory and semantic fluency, cognitive impairment in BD II is as severe as in BD I. Further studies are needed to investigate whether more severe deficits in BD I are related to neurotoxic effects of severe manic episodes on medial temporal structures or neurobiological differences from the onset of the illness.
Language eng
Field of Research 110319 Psychiatry (incl Psychotherapy)
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2011, Wiley-Blackwell Publishing, Inc.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30045336

Document type: Journal Article
Collection: School of Medicine
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