25-Hydroxyvitamin D levels and chronic kidney disease in the AusDiab (Australian Diabetes, Obesity and Lifestyle) study

Damasiewicz, Matthew J., Magliano, Dianna J., Daly, Robin M., Gagnon, Claudia, Lu, Zhong X., Ebeling, Peter R., Chadban, Steven J., Atkins, Robert C., Kerr, Peter G., Shaw, Jonathan E. and Polkinghorne, Kevan R. 2012, 25-Hydroxyvitamin D levels and chronic kidney disease in the AusDiab (Australian Diabetes, Obesity and Lifestyle) study, BMC Nephrology, vol. 13, no. 55, pp. 1-18.

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Title 25-Hydroxyvitamin D levels and chronic kidney disease in the AusDiab (Australian Diabetes, Obesity and Lifestyle) study
Author(s) Damasiewicz, Matthew J.
Magliano, Dianna J.
Daly, Robin M.
Gagnon, Claudia
Lu, Zhong X.
Ebeling, Peter R.
Chadban, Steven J.
Atkins, Robert C.
Kerr, Peter G.
Shaw, Jonathan E.
Polkinghorne, Kevan R.
Journal name BMC Nephrology
Volume number 13
Issue number 55
Start page 1
End page 18
Total pages 18
Publisher BioMed Central
Place of publication London, England
Publication date 2012
ISSN 1471-2369
Summary Background : Low 25-hydroxy vitamin D (25(OH)D) levels have been associated with an increased risk of albuminuria, however an association with glomerular filtration rate (GFR) is not clear. We explored the relationship between 25(OH)D levels and prevalent chronic kidney disease (CKD), albuminuria and impaired GFR, in a national, population-based cohort of Australian adults (AusDiab Study).

Methods :
10,732 adults [greater than or equal to]25 years of age participating in the baseline survey of the AusDiab study (1999-2000) were included. The GFR was estimated using an enzymatic creatinine assay and the CKD-EPI equation, with CKD defined as eGFR <60ml/min/1.73 m2. Albuminuria was defined as a spot urine albumin to creatinine ratio (ACR) of [greater than or equal to]2.5 mg/mmol for men and [greater than or equal to]3.5 for women. Serum 25(OH)D levels of <50 nmol/L were considered vitamin D deficient. The associations between 25(OH)D level, albuminuria and impaired eGFR were estimated using multivariate regression models.

Results :
30.7% of the study population had a 25(OH)D level <50 nmol/L (95% CI 25.6-35.8). 25(OH)D deficiency was significantly associated with an impaired eGFR in the univariate model (OR 1.52, 95% CI 1.07-2.17), but not in the multivariate model (OR 0.95, 95% CI 0.67-1.35). 25(OH)D deficiency was significantly associated with albuminuria in the univariate (OR 2.05, 95% CI 1.58-2.67) and multivariate models (OR 1.54, 95% CI 1.14-2.07).

Conclusions : Vitamin D deficiency is common in this population, and 25(OH)D levels of <50 nmol/L were independently associated with albuminuria, but not with impaired eGFR. These associations warrant further exploration in prospective and interventional studies
Language eng
Field of Research 110306 Endocrinology
Socio Economic Objective 920106 Endocrine Organs and Diseases (excl. Diabetes)
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2012, The Authors
Persistent URL http://hdl.handle.net/10536/DRO/DU:30046126

Document type: Journal Article
Collection: Centre for Physical Activity and Nutrition Research
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Created: Tue, 17 Jul 2012, 10:12:53 EST by Jane Moschetti

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