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Breaking up prolonged sitting reduces postprandial glucose and insulin responses

Dunstan, David W, Kingwell, Bronwyn A., Larsen, Robyn, Healy, Genevieve N., Cerin, Ester, Hamilton, Marc T., Shaw, Jonathan, Bertovic, David A., Zimmet, Paul Z., Salmon, Jo and Owen, Neville 2012, Breaking up prolonged sitting reduces postprandial glucose and insulin responses, Diabetes care, vol. 35, no. 5, pp. 976-983.

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Title Breaking up prolonged sitting reduces postprandial glucose and insulin responses
Author(s) Dunstan, David W
Kingwell, Bronwyn A.
Larsen, Robyn
Healy, Genevieve N.
Cerin, Ester
Hamilton, Marc T.
Shaw, Jonathan
Bertovic, David A.
Zimmet, Paul Z.
Salmon, Jo
Owen, Neville
Journal name Diabetes care
Volume number 35
Issue number 5
Start page 976
End page 983
Total pages 8
Publisher American Diabetes Association
Place of publication Alexandria, Va.
Publication date 2012-05-01
ISSN 0149-5992
Keyword(s) prolonged sitting
insulin
glucose
Summary OBJECTIVE--Observational studies show breaking up prolonged sitting has beneficial associations with cardiometabolic risk markers, but intervention studies are required to investigate causality. We examined the acute effects on postprandial glucose and insulin levels of uninterrupted sitting compared with sitting interrupted by brief bouts of light- or moderate-intensity walking.

RESEARCH DESIGN AND METHODS--Overweight/obese adults (n = 19), aged 45-65 years, were recruited for a randomized three-period, three-treatment acute crossover trial: I) uninterrupted sitting; 2) seated with 2-min bouts of light-intensity walking every 20 rain; and 3) seated with 2-min bouts of moderate-intensity walking every 20 min. A standardized test drink was provided after an initial 2-h period of uninterrupted sitting. The positive incremental area under curves (iAUC) for glucose and insulin (mean [95% CI]) for the 5 h after the test drink (75 g glucose, 50 g fat) were calculated for the respective treatments.

RESULTS--The glucose iAUC (mmol/L) x h after both activity-break conditions was reduced (light: 5.2 [4.1-6.6]; moderate: 4.9 [3.8-6.1]; both P < 0.01) compared with uninterrupted sitting (6.9 [5.5-8.7]). Insulin iAUC (pmol/L) x h was also reduced with both activity-break conditions (light: 633.6 [552.4-727.1]; moderate: 637.6 [555.5-731.9], P < 0.0001) compared with uninterrupted sitting (828.6 [722.0-950.9]).

CONCLUSIONS--Interrupting sitting time with short bouts of light- or moderate-intensity walking lowers postprandial glucose and insulin levels in overweight/obese adults. This may improve glucose metabolism and potentially be an important public health and clinical intervention strategy for reducing cardiovascular risk.
Language eng
Field of Research 110699 Human Movement and Sports Science not elsewhere classified
Socio Economic Objective 920401 Behaviour and Health
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2012, American Diabetes Association
Persistent URL http://hdl.handle.net/10536/DRO/DU:30046262

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Created: Thu, 26 Jul 2012, 13:32:48 EST by Jane Moschetti