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Associations between smoking status, lifestyle and lipoprotein subclasses

Beauchamp, A. J., Tonkin, A. M., Peeters, A., Wolfe, R., Turrell, G., Harriss, L., Giles, G. and Jenkins, A. 2010, Associations between smoking status, lifestyle and lipoprotein subclasses, in ESC Congress 2010 : Proceedings of the European Society of Cardiology Congress, Oxford University Press, [Stockholm, Sweden], doi: 10.1093/eurheartj/ehq289.

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Title Associations between smoking status, lifestyle and lipoprotein subclasses
Author(s) Beauchamp, A. J.ORCID iD for Beauchamp, A. J. orcid.org/0000-0001-6555-6200
Tonkin, A. M.
Peeters, A.
Wolfe, R.
Turrell, G.
Harriss, L.
Giles, G.
Jenkins, A.
Conference name European Society of Cardiology. Congress (2010 : Stockholm, Sweden)
Conference location Stockholm, Sweden
Conference dates 28 Aug.-1 Sep. 2010
Title of proceedings ESC Congress 2010 : Proceedings of the European Society of Cardiology Congress
Editor(s) [Unknown]
Publication date 2010
Conference series European Society of Cardiology. Congress
Publisher Oxford University Press
Place of publication [Stockholm, Sweden]
Summary Background: Although the relationship between cigarette smoking and cardiovascular disease (CVD) is well-established, the underlying mechanisms remain unclear. Smokers have a more atherogenic lipid profile but this may be mediated by lifestyle-related factors. Because detailed analysis of lipoprotein subclasses using nuclear magnetic resonance spectroscopy (NMR) may improve characterisation of lipid abnormalities, we applied the technique to investigate the relationships between smoking status, other lifestyle-related risk factors and lipoproteins in a contemporary cohort.

Methods: A total of 612 participants (360 women) aged 40-69 years at baseline (1990-1994) enrolled in the community-based Melbourne Collaborative Cohort Study had plasma lipoproteins measured using NMR. Data were analysed separately for men and women.

Results: After adjusting for other lifestyle-related risk factors, mean total low-density lipoprotein (LDL) particle concentration was higher for female smokers than non-smokers. Both medium and small LDL particle concentrations contributed to this difference. Both total high-density lipoprotein (HDL) and large HDL particle concentrations were lower for female smokers than non-smokers. The proportion at increased risk (according to NMR-determined particle size and number) was higher for female smokers than non-smokers. For men, there were few differences in lipoprotein measures related to smoking.

Conclusions: Female smokers have a more atherogenic lipoprotein profile than non-smokers, and this difference is independent of lifestyle-related risk factors. Lipoprotein profiles did not differ greatly between male smokers and non-smokers. These data reinforce the importance for women of not smoking.
Notes This abstract was published in the European Heart Journal ( 2010 ) 31 ( Abstract Supplement ), 681
Language eng
DOI 10.1093/eurheartj/ehq289
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category E3.1 Extract of paper
Copyright notice ©2010, Oxford University Press
Persistent URL http://hdl.handle.net/10536/DRO/DU:30046455

Document type: Conference Paper
Collections: School of Health and Social Development
Population Health
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