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The need to examine metastatic tissue at the time of progression of breast cancer : is re-biopsy a necessity or a luxury?

Khasraw, Mustafa, Brogi, Edi and Seidman, Andrew D. 2011, The need to examine metastatic tissue at the time of progression of breast cancer : is re-biopsy a necessity or a luxury?, Current oncology reports, vol. 13, no. 1, pp. 17-25, doi: 10.1007/s11912-010-0137-9.

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Title The need to examine metastatic tissue at the time of progression of breast cancer : is re-biopsy a necessity or a luxury?
Author(s) Khasraw, MustafaORCID iD for Khasraw, Mustafa orcid.org/0000-0003-3249-9849
Brogi, Edi
Seidman, Andrew D.
Journal name Current oncology reports
Volume number 13
Issue number 1
Start page 17
End page 25
Total pages 9
Publisher Springer
Place of publication [Philadelphia, Pa.]
Publication date 2011-02
ISSN 1523-3790
1534-6269
Keyword(s) tissue biopsy
metastases
breast cancer
estrogen receptor
ER
progesterone receptor
PgR
human epidermal growth factor receptor-2
HER2
Summary Knowledge of estrogen receptor (ER), progesterone receptor (PgR) and human epidermal growth factor receptor-2 (HER2) status is necessary for determining the optimal treatment of breast cancer patients. At the same time, the discordance between marker profiles (ER/PR and HER2) of primary and metastatic breast cancer is well documented. Whether discordant cases are secondary to “clonal selection” in the face of targeted anti-estrogen or anti-HER2 therapy or whether they are a laboratory artifact is still debated; both scenarios are likely. This article outlines current modalities for ER, PR, and HER2 testing in primary breast carcinoma and its metastases and reviews prospective and retrospective studies that have addressed these issues, as well as recent advances in the field.
Language eng
DOI 10.1007/s11912-010-0137-9
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C3.1 Non-refereed articles in a professional journal
Copyright notice ©2010, Springer Science+Business Media, LLC
Persistent URL http://hdl.handle.net/10536/DRO/DU:30046483

Document type: Journal Article
Collection: School of Medicine
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