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Advances in the treatment of malignant gliomas

Khasraw, Mustafa and Lassman, Andrew B. 2010, Advances in the treatment of malignant gliomas, Current oncology reports, vol. 12, no. 1, pp. 26-33, doi: 10.1007/s11912-009-0077-4.

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Title Advances in the treatment of malignant gliomas
Author(s) Khasraw, MustafaORCID iD for Khasraw, Mustafa orcid.org/0000-0003-3249-9849
Lassman, Andrew B.
Journal name Current oncology reports
Volume number 12
Issue number 1
Start page 26
End page 33
Total pages 8
Publisher Springer Healthcare
Place of publication Philadelphia, Pa.
Publication date 2010-01
ISSN 1523-3790
1534-6269
Keyword(s) antiangiogenic therapy
bevacizumab
glioblastoma
temozolomide
Summary Local control with surgery, radiation, and temozolomide chemotherapy remain the pillars of treatment for high-grade gliomas. Novel therapeutic strategies, including a variety of antiangiogenic agents, are under investigation. One of these agents, bevacizumab, was recently given accelerated approval by the US Food and Drug Administration as a single agent for recurrent glioblastoma. Recent trial results are generating important clinical questions regarding which patients to treat and when, and how best to monitor response. Encouraging results of recent studies are driving willingness to undertake aggressive treatment and to improve outcomes in this population. In this era, better understanding of biology, molecular aspects of cancer, and clinical trial methodology are crucial for clinicians. This review focuses on recent advances in the treatment malignant gliomas, especially antiangiogenic therapy.
Language eng
DOI 10.1007/s11912-009-0077-4
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2010, Springer Science+Business Media, LLC
Persistent URL http://hdl.handle.net/10536/DRO/DU:30046491

Document type: Journal Article
Collection: School of Medicine
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