Epidemiologic merit of obese-years, the combination of degree and duration of obesity

Abdullah, Asnawi, Wolfe, Rory, Mannan, Haider, Stoelwinder, Johannes U., Stevenson, Christopher and Peeters, Anna 2012, Epidemiologic merit of obese-years, the combination of degree and duration of obesity, American journal of epidemiology, vol. 176, no. 2, pp. 99-107.

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Title Epidemiologic merit of obese-years, the combination of degree and duration of obesity
Author(s) Abdullah, Asnawi
Wolfe, Rory
Mannan, Haider
Stoelwinder, Johannes U.
Stevenson, Christopher
Peeters, Anna
Journal name American journal of epidemiology
Volume number 176
Issue number 2
Start page 99
End page 107
Total pages 9
Publisher Oxford University Press
Place of publication Cary, N. C.
Publication date 2012-06-28
ISSN 0002-9262
1476-6256
Keyword(s) body mass index
duration of obesity
obese-years
obesity
total exposure
type-2 diabetes
Summary This study aims to test the effect of combining the degree and the duration of obesity into a single variable-obese-years-and to examine whether obese-years is a better predictor of the risk of diabetes than simply body mass index (BMI) or duration of obesity. Of the original cohort of the Framingham Heart Study, 5,036 participants were followed up every 2 years for up to 48 years (from 1948). The variable, obese-years, was defined by multiplying for each participant the number of BMI units above 30 kg/m(2) by the number of years lived at that BMI. Associations with diabetes were analyzed by using time-dependent Cox proportional hazards regression models adjusted for potential confounders. The incidence of type-2 diabetes increased as the number of obese-years increased, with adjusted hazard ratios of 1.07 (95% confidence interval: 1.06, 1.09) per additional 10 obese-years. The dose-response relation between diabetes incidence and obese-years varied by sex and smoking status. The Akaike Information Criterion was lowest in the model containing obese-years compared with models containing either the degree or duration of obesity alone. A construct of obese-years is strongly associated with risk of diabetes and could be a better indicator of the health risks associated with increasing body weight than BMI or duration of obesity alone.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30046758

Document type: Journal Article
Collection: School of Health and Social Development
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