The number of years lived with obesity and the risk of all-cause and cause-specific mortality

Abdullah, Asnawi, Wolfe, Rory, Stoelwinder, Johannes U., de Courten, Maximilian, Stevenson, Christopher, Walls, Helen L. and Peeters, Anna 2011, The number of years lived with obesity and the risk of all-cause and cause-specific mortality, International journal of epidemiology, vol. 40, no. 4, pp. 985-996.

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Title The number of years lived with obesity and the risk of all-cause and cause-specific mortality
Author(s) Abdullah, Asnawi
Wolfe, Rory
Stoelwinder, Johannes U.
de Courten, Maximilian
Stevenson, Christopher
Walls, Helen L.
Peeters, Anna
Journal name International journal of epidemiology
Volume number 40
Issue number 4
Start page 985
End page 996
Total pages 12
Publisher Oxford University Press
Place of publication Oxford, England
Publication date 2011-08
ISSN 0300-5771
1464-3685
Keyword(s) all-cause mortality
body mass index
cause-specific mortality
duration of obesity
mortality
obesity
Summary Background The role of the duration of obesity as an independent risk factor for mortality has not been investigated. The aim of this study was to analyse the association between the duration of obesity and the risk of mortality.

Methods A total of 5036 participants (aged 28–62 years) of the Framingham Cohort Study were followed up every 2 years from 1948 for up to 48 years. The association between obesity duration and all-cause and cause-specific mortality was analysed using time-dependent Cox models adjusted for body mass index. The role of biological intermediates and chronic diseases was also explored.

Results The adjusted hazard ratio (HR) for mortality increased as the number of years lived with obesity increased. For those who were obese for 1–4.9, 5–14.9, 15–24.9 and ≥25 years of the study follow-up period, adjusted HRs for all-cause mortality were 1.51 [95% confidence interval (CI) 1.27–1.79], 1.94 (95% CI 1.71–2.20), 2.25 (95% CI 1.89–2.67) and 2.52 (95% CI 2.08–3.06), respectively, compared with those who were never obese. A dose–response relation between years of duration of obesity was also clear for all-cause, cardiovascular, cancer and other-cause mortality. For every additional 2 years of obesity, the HRs for all-cause, cardiovascular disease, cancer and other-cause mortality were 1.06 (95% CI 1.05–1.07), 1.07 (95% CI 1.05–1.08), 1.03 (95% CI 1.01–1.05) and 1.07 (95% CI 1.05–1.11), respectively.

Conclusions The number of years lived with obesity is directly associated with the risk of mortality. This needs to be taken into account when estimating its burden on mortality.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30046759

Document type: Journal Article
Collection: School of Health and Social Development
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