The duration of obesity and the risk of type-2 diabetes

Abdullah, Asnawi, Stoelwinder, Johannes, Shortreed, Susan, Wolfe, Rory, Stevenson, Christopher, Walls, Helen, de Courten, Maximilian and Peeters, Anna 2011, The duration of obesity and the risk of type-2 diabetes, Public health nutrition, vol. 14, no. 1, pp. 119-126.

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Title The duration of obesity and the risk of type-2 diabetes
Author(s) Abdullah, Asnawi
Stoelwinder, Johannes
Shortreed, Susan
Wolfe, Rory
Stevenson, Christopher
Walls, Helen
de Courten, Maximilian
Peeters, Anna
Journal name Public health nutrition
Volume number 14
Issue number 1
Start page 119
End page 126
Total pages 8
Publisher Cambridge University Press
Place of publication Cambridge, England
Publication date 2011-01
ISSN 1368-9800
1475-2727
Keyword(s) obesity
duration of obesity
body mass index
type 2 diabetes
Framingham heart study
Summary Objective The evidence for the association between obesity and the risk of type 2 diabetes has been derived mainly from the analysis of the degree of obesity. The role of the duration of obesity as an independent risk has not been fully explored. The objective of the present study was to investigate the association between the duration of obesity and the risk of type 2 diabetes.

Design Prospective cohort study.

Setting The Framingham Heart Study (FHS), follow-up from 1948 to 1998.

Subjects A total of 1256 FHS participants who were free from type 2 diabetes at baseline, but were obese on at least two consecutive of the study’s twenty-four biennial examinations, were included. Type 2 diabetes status was collected throughout the 48 years of follow-up of the study. The relationship between duration of obesity and type 2 diabetes was analysed using time-dependent Cox models, adjusting for a number of covariates.

Results The unadjusted hazard ratio (HR) for the risk of type 2 diabetes for men was 1·13 (95 % CI 1·09, 1·17) and for women was 1·12 (95 % CI 1·08, 1·16) per additional 2-year increase in the duration of obesity. Adjustment for sociodemographic variables, family history of diabetes, health behaviour and physical activity made little difference to these HR. For women the evidence of a dose–response relationship was less clear than for men, particularly for women with an older age at obesity onset.

Conclusions The duration of obesity is a relevant risk factor for type 2 diabetes, independent of the degree of BMI.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2010, The Authors
Persistent URL http://hdl.handle.net/10536/DRO/DU:30046766

Document type: Journal Article
Collection: School of Health and Social Development
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