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Evolution of JAK-STAT pathway components : mechanisms and role in immune system development Liongue, Clifford, O'Sullivan, Lynda A., Trengove, Monique C. and Ward, Alister C. 2012, Evolution of JAK-STAT pathway components : mechanisms and role in immune system development, PLoS one, vol. 7, no. 3, pp. 1-16. Attached Files Name Description MIMEType Size Downloads liongue-evolutionof-2012.pdf Published version application/pdf 1.59MB 95 Title Evolution of JAK-STAT pathway components : mechanisms and role in immune system development Author(s) Liongue, Clifford O'Sullivan, Lynda A. Trengove, Monique C. Ward, Alister C. Journal name PLoS one Volume number 7 Issue number 3 Start page 1 End page 16 Total pages 16 Publisher Public Library of Science Place of publication San Francisco, Calif. Publication date 2012-03-07 ISSN 1932-6203 Keyword(s) protein-tyrosine-phosphatase signaling pathways jak/stat pathway genome duplication cytokine receptors interleukin-2 il-2 adaptive immunity gene-activation socs proteins pias proteins Summary Background Lying downstream of a myriad of cytokine receptors, the Janus kinase (JAK) – Signal transducer and activator of transcription (STAT) pathway is pivotal for the development and function of the immune system, with additional important roles in other biological systems. To gain further insight into immune system evolution, we have performed a comprehensive bioinformatic analysis of the JAK-STAT pathway components, including the key negative regulators of this pathway, the SH2-domain containing tyrosine phosphatase (SHP), Protein inhibitors against Stats (PIAS), and Suppressor of cytokine signaling (SOCS) proteins across a diverse range of organisms. Results Our analysis has demonstrated significant expansion of JAK-STAT pathway components co-incident with the emergence of adaptive immunity, with whole genome duplication being the principal mechanism for generating this additional diversity. In contrast, expansion of upstream cytokine receptors appears to be a pivotal driver for the differential diversification of specific pathway components. Conclusion Diversification of JAK-STAT pathway components during early vertebrate development occurred concurrently with a major expansion of upstream cytokine receptors and two rounds of whole genome duplications. This produced an intricate cell-cell communication system that has made a significant contribution to the evolution of the immune system, particularly the emergence of adaptive immunity. Notes This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Language eng Field of Research 069999 Biological Sciences not elsewhere classified Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences HERDC Research category C1 Refereed article in a scholarly journal Copyright notice ©2012, Liongue et al. Persistent URL http://hdl.handle.net/10536/DRO/DU:30046879 Document type: Journal Article Collections: School of Medicine School of Life and Environmental Sciences Open Access Collection Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Mon, 13 Aug 2012, 12:37:31 EST Mon, 20 Aug 2012, 14:47:09 EST Mon, 20 Aug 2012, 14:54:45 EST Filtered Full Citation counts: Cited 6 times in Scopus Search Google Scholar Access Statistics: 37 Abstract Views, 96 File Downloads  -  Detailed Statistics Created: Mon, 13 Aug 2012, 12:37:31 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.