Enhanced cell growth using non-woven scaffolds of multilobal fibres

Wong, Cynthia S., Nuhiji, Edin, Sutti, Alessandra, Keating, Graeme, Liu, Xin, Kirkland, Mark and Wang, Xungai 2012, Enhanced cell growth using non-woven scaffolds of multilobal fibres, Textile research journal, vol. 82, no. 13, pp. 1371-1381.

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Title Enhanced cell growth using non-woven scaffolds of multilobal fibres
Author(s) Wong, Cynthia S.
Nuhiji, Edin
Sutti, Alessandra
Keating, Graeme
Liu, Xin
Kirkland, Mark
Wang, Xungai
Journal name Textile research journal
Volume number 82
Issue number 13
Start page 1371
End page 1381
Total pages 11
Publisher Sage Publications
Place of publication London, England
Publication date 2012-08
ISSN 0040-5175
1746-7748
Keyword(s) fibroblast
multilobal fibres
non-woven scaffolds
SaOS2 cells
tissue engineering
Summary Multilobal fibres contain several grooves and have higher surface area than round fibres. Cell density can be enhanced when cultured on scaffolds manufactured with multilobal fibres. This study compared the cell growth of dermal fibroblasts and osteoblast-like SaOS2 cells on polymeric scaffolds produced from multilobal fibres to the conventional round-fibred scaffolds. Cells were cultured on round nylon 6,6, trilobal nylon 6,6, round polyethylene terephthalate (PET) and multilobal PET scaffolds for 14 days. There were more cells cultured on trilobal nylon 6,6 and PET multilobal scaffolds than their round counterparts. Preference to the type of multilobal scaffolds was cell dependent. Fibroblasts increased by 21.8 ± 1.9 fold to 6.3 × 105 cells (p < 0.001) when cultured on trilobal nylon 6,6 scaffolds while SaOS2 cells exhibited a 16.7 ± 2.8 fold increase (2.9 × 105 cells, p < 0.001) on the multilobal PET scaffolds after 14 days of culture. The ability of multilobal fibres to accommodate large quantities of cells presents an excellent alternative to round fibres as scaffolds for tissue engineering.
Language eng
Field of Research 060106 Cellular Interactions (incl Adhesion, Matrix, Cell Wall)
090301 Biomaterials
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2012, The Author(s)
Persistent URL http://hdl.handle.net/10536/DRO/DU:30046994

Document type: Journal Article
Collection: Institute for Frontier Materials
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