Lack of ceruloplasmin expression alters aspects of copper transport to the fetus and newborn, as determined in mice

Chu, Yu-Ling, Sauble, Eric N., Cabrera, Anthony, Roth, Aleeza, Ackland, M. Leigh, Mercer, Julian F. B. and Linder, Maria C. 2012, Lack of ceruloplasmin expression alters aspects of copper transport to the fetus and newborn, as determined in mice, BioMetals, vol. 25, no. 2, pp. 373-382.

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Title Lack of ceruloplasmin expression alters aspects of copper transport to the fetus and newborn, as determined in mice
Author(s) Chu, Yu-Ling
Sauble, Eric N.
Cabrera, Anthony
Roth, Aleeza
Ackland, M. Leigh
Mercer, Julian F. B.
Linder, Maria C.
Journal name BioMetals
Volume number 25
Issue number 2
Start page 373
End page 382
Total pages 10
Publisher Springer Netherlands
Place of publication Dordrecht, The Netherlands
Publication date 2012-04
ISSN 0966-0844
1572-8773
Keyword(s) ceruloplasmin
copper
copper-64
iron
mammary gland
milk
Summary Copper transport and accumulation were studied in virgin and lactating C57BL/6 mice, with and without expression of ceruloplasmin (Cp), to assess the importance of Cp to these processes. One hour after i.p. injection of tracer 64Cu, liver and kidney accounted for 80% of the radioactivity, and mammary gland 1%, while in lactating Cp+/+ mice 2–4 days post partum, uptake by mammary gland was 9-fold higher and that of liver and other organs was decreased, with 64Cu rapidly appearing in milk. Parallel studies in Cp−/− mice (siblings from same colony) gave virtually identical results. However, their milk contained less 64Cu, and actual copper contents determined by furnace atomic absorption were less than half those for milk from normal dams. Liver copper concentrations of pups born to Cp−/− dams also were half those of pups from wild type dams. Copper in pup brains was unaffected; but iron concentrations were reduced. We conclude that absence of Cp, while not affecting entry of exchangeable copper from the blood into the mammary gland, does have a significant effect on the availability of this metal to the newborn through the milk and in the form of stores accumulating in gestation.
Language eng
Field of Research 069999 Biological Sciences not elsewhere classified
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2011, Springer Science+Business Media
Persistent URL http://hdl.handle.net/10536/DRO/DU:30047039

Document type: Journal Article
Collection: School of Life and Environmental Sciences
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