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The antimicrobial efficacy of elaeis guineensis : characterization, in Vitro and in Vivo studies

Vijayarathna, Soundararajan, Zakaria, Zuraini, Chen, Yeng, Latha, Lachimanan Yoga, Kanwar, Jagat R. and Sasidharan, Sreenivasan 2012, The antimicrobial efficacy of elaeis guineensis : characterization, in Vitro and in Vivo studies, Molecules, vol. 17, no. 5, pp. 4860-4877.

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Title The antimicrobial efficacy of elaeis guineensis : characterization, in Vitro and in Vivo studies
Formatted title The antimicrobial efficacy of elaeis guineensis : characterization, in Vitro and in Vivo studies
Author(s) Vijayarathna, Soundararajan
Zakaria, Zuraini
Chen, Yeng
Latha, Lachimanan Yoga
Kanwar, Jagat R.
Sasidharan, Sreenivasan
Journal name Molecules
Volume number 17
Issue number 5
Start page 4860
End page 4877
Total pages 18
Publisher M D P I AG
Place of publication Basel, Switzerland
Publication date 2012
ISSN 1420-3049
Keyword(s) antimicrobial activity
Candida albicans
Elaeis guineensis
scanning electron microscopy
transmission electron microscopy
Summary The urgent need to treat multi-drug resistant pathogenic microorganisms in chronically infected patients has given rise to the development of new antimicrobials from natural resources. We have tested Elaeis guineensis Jacq (Arecaceae) methanol extract against a variety of bacterial, fungal and yeast strains associated with infections. Our studies have demonstrated that E. guineensis exhibits excellent antimicrobial activity in vitro and in vivo against the bacterial and fungal strains tested. A marked inhibitory effect of the E. guineensis extracts was observed against C. albicans whereby E. guineensis extract at =, 1, or 2 times the MIC significantly inhibited C. albicans growth with a noticeable drop in optical density (OD) of the bacterial culture. This finding confirmed the anticandidal activity of the extract on C. albicans. Imaging using scanning (SEM) and transmission (TEM) electron microscopy was done to determine the major alterations in the microstructure of the extract-treated C. albicans. The main abnormalities noted via SEM and TEM studies were the alteration in morphology of the yeast cells. In vivo antimicrobial activity was studied in mice that had been inoculated with C. albicans and exhibited good anticandidal activity. The authors conclude that the extract may be used as a candidate for the development of anticandidal agent.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2012, The Authors and M D P I AG
Persistent URL http://hdl.handle.net/10536/DRO/DU:30047101

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