Emerging engineered magnetic nanoparticulate probes for molecular MRI of atherosclerosis : how far have we come?

Kanwar, Rupinder K., Chaudhary, Rajneesh, Tsuzuki, Takuya and Kanwar, Jagat R. 2012, Emerging engineered magnetic nanoparticulate probes for molecular MRI of atherosclerosis : how far have we come?, Nanomedicine, vol. 7, no. 6, pp. 899-916.

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Title Emerging engineered magnetic nanoparticulate probes for molecular MRI of atherosclerosis : how far have we come?
Author(s) Kanwar, Rupinder K.
Chaudhary, Rajneesh
Tsuzuki, Takuya
Kanwar, Jagat R.
Journal name Nanomedicine
Volume number 7
Issue number 6
Start page 899
End page 916
Total pages 18
Publisher Future Medicine
Place of publication London, England
Publication date 2012
ISSN 1743-5889
1748-6963
Keyword(s) angiogenesis
atherosclerosis
cell adhesion molecules
gadolinium
heat shock proteins
iron oxide nanopJournal Articles
MRI platelets
Summary Atherosclerosis is a chronic, progressive, immunoinflammatory disease of the large and medium-sized arteries, and a major cause of cardiovascular diseases. Atherosclerosis often progresses silently for decades until the occurrence of a major catastrophic clinical event such as myocardial infarction, cardiac arrest and stroke. The main challenge in the diagnosis and management of atherosclerosis is to develop a safe, noninvasive technique that is accurate and reproducible, which can detect the biologically active high-risk vulnerable plaques (with ongoing active inflammation, angiogenesis and apoptosis) before the occurrence of an acute clinical event. This Journal Article reviews the events involved in the pathogenesis of atherosclerosis in light of recently advanced understanding of the molecular pathogenesis of the disease. Next, we elaborate on the interesting developments in molecular MRI, by describing the recently engineered magnetic nanoparticulate probes targeting clinically promising molecular and cellular players/processes, involved in early atherosclerotic lesion formation to plaque rupture and erosion.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2012, Future Medicine
Persistent URL http://hdl.handle.net/10536/DRO/DU:30047102

Document type: Journal Article
Collection: Institute for Frontier Materials
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