The neuroprogressive nature of major depressive disorder: pathways to disease evolution and resistance, and therapeutic implications

Moylan, S., Maes, M., Wray, N. R. and Berk, M. 2013, The neuroprogressive nature of major depressive disorder: pathways to disease evolution and resistance, and therapeutic implications, Molecular psychiatry, vol. 18, pp. 595-606.

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Title The neuroprogressive nature of major depressive disorder: pathways to disease evolution and resistance, and therapeutic implications
Author(s) Moylan, S.
Maes, M.
Wray, N. R.
Berk, M.
Journal name Molecular psychiatry
Volume number 18
Start page 595
End page 606
Total pages 12
Publisher Nature Publishing Group
Place of publication London, England
Publication date 2013
ISSN 1476-5578
Keyword(s) cytokines
oxidative stress
nitrosative stress
neuroprogression
inflammation
depression
Summary In some patients with major depressive disorder (MDD), individual illness characteristics appear consistent with those of a neuroprogressive illness. Features of neuroprogression include poorer symptomatic, treatment and functional outcomes in patients with earlier disease onset and increased number and length of depressive episodes. In such patients, longer and more frequent depressive episodes appear to increase vulnerability for further episodes, precipitating an accelerating and progressive illness course leading to functional decline. Evidence from clinical, biochemical and neuroimaging studies appear to support this model and are informing novel therapeutic approaches. This paper reviews current knowledge of the neuroprogressive processes that may occur in MDD, including structural brain consequences and potential molecular mechanisms including the role of neurotransmitter systems, inflammatory, oxidative and nitrosative stress pathways, neurotrophins and regulation of neurogenesis, cortisol and the hypothalamic–pituitary–adrenal axis modulation, mitochondrial dysfunction and epigenetic and dietary influences. Evidence-based novel treatments informed by this knowledge are discussed.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2012, Nature Publishing Group
Persistent URL http://hdl.handle.net/10536/DRO/DU:30047118

Document type: Journal Article
Collection: School of Medicine
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Created: Mon, 13 Aug 2012, 14:53:49 EST by Jane Moschetti

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