Early inflammatory and myogenic responses to resistance exercise in the elderly

Mathers, Jessica L., Farnfield, Michelle M., Garnham, Andrew P., Caldow, Marissa K., Cameron-Smith, David and Peake, Jonathon M. 2012, Early inflammatory and myogenic responses to resistance exercise in the elderly, Muscle and Nerve, vol. 46, no. 3, pp. 407-412.

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Title Early inflammatory and myogenic responses to resistance exercise in the elderly
Author(s) Mathers, Jessica L.
Farnfield, Michelle M.
Garnham, Andrew P.
Caldow, Marissa K.
Cameron-Smith, David
Peake, Jonathon M.
Journal name Muscle and Nerve
Volume number 46
Issue number 3
Start page 407
End page 412
Total pages 6
Publisher John Wiley & Sons, Inc.
Place of publication Hoboken N.J.
Publication date 2012-09
ISSN 0148-639X
Keyword(s) aging
regeneration
myokine
muscle damage
inflammation
Summary Introduction and Methods: This study compared changes in myokine and myogenic genes following resistance exercise (3 sets of 12 repetitions of maximal unilateral knee extension) in 20 elderly men (67.8 ± 1.0 years) and 15 elderly women (67.2 ± 1.5 years). Results: Monocyte chemotactic protein (MCP)-1, macrophage inhibitory protein (MIP)-1β, interleukin (IL)-6 and MyoD mRNA increased significantly (P < 0.05), whereas myogenin and myostatin mRNA decreased significantly after exercise in both groups. Macrophage-1 (Mac-1) and MCP-3 mRNA did not change significantly after exercise in either group. MIP-1β, Mac-1 and myostatin mRNA were significantly higher before and after exercise in men compared with women. In contrast, MCP-3 and myogenin mRNA were significantly higher before and after exercise in the women compared with the men. Conclusions: In elderly individuals, gender influences the mRNA expression of certain myokines and growth factors, both at rest and after resistance exercise. These differences may influence muscle regeneration following muscle injury.
Language eng
Field of Research 060103 Cell Development, Proliferation and Death
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2012, John Wiley & Sons, Inc.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30047159

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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