Illness burden and medical comorbidity in the systematic treatment enhancement program for bipolar disorder

Magalhaes, P. V., Kapczinski, F., Nierenberg, A. A., Deckersbach, T., Weisinger, D., Dodd, S. and Berk, M. 2012, Illness burden and medical comorbidity in the systematic treatment enhancement program for bipolar disorder, Acta psychiatrica scandinavica, vol. 125, no. 4, pp. 303-308.

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Title Illness burden and medical comorbidity in the systematic treatment enhancement program for bipolar disorder
Author(s) Magalhaes, P. V.
Kapczinski, F.
Nierenberg, A. A.
Deckersbach, T.
Weisinger, D.
Dodd, S.
Berk, M.
Journal name Acta psychiatrica scandinavica
Volume number 125
Issue number 4
Start page 303
End page 308
Total pages 6
Publisher Wiley - Blackwell Publishing
Place of publication Malden, Mass.
Publication date 2012-04
ISSN 0001-690X
1600-0447
Keyword(s) bipolar disorder
medical burden
staging
age at onset
comorbidity
outcome
treatment
mania
depression
course
diabetes
smoking
cardiovascular
Summary Objective:  Coexisting chronic medical conditions are common in bipolar disorder. Here, we report the prevalence and correlates of medical comorbidity in patients enrolled in the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD). We were particularly interested in associations between variables reflecting illness chronicity and burden with comorbid medical conditions.

Method:  We used intake data from the open-label component of the STEP-BD. History of medical comorbidity was obtained from the affective disorders evaluation, and its presence was the outcome of interest. The sample size in analyses varied from 3399 to 3534. We used multiple Poisson regression to obtain prevalence ratios.

Results:  The prevalence of any medical comorbidity in the sample was 58.8%. In addition to demographic variable, several clinical characteristics were associated with the frequency of medical comorbidity. Having more than 10 previous mood episodes, childhood onset, smoking, lifetime comorbidity with anxiety, and substance use disorders were independently associated with having a medical comorbidity in the final multivariate model.

Conclusion:  The results presented here reveal strong associations between variables related to illness chronicity and medical burden in bipolar disorder. This lends further support to recent multidimensional models incorporating medical morbidity as a core feature of bipolar disorder.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2011, John Wiley & Sons A/S
Persistent URL http://hdl.handle.net/10536/DRO/DU:30047211

Document type: Journal Article
Collection: School of Medicine
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