Lipid membrane : a novel target for viral and bacterial pathogens

Hawkes, David J. and Mak, Johnson 2006, Lipid membrane : a novel target for viral and bacterial pathogens, Current drug target, vol. 7, no. 12, pp. 1615-1621.

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Title Lipid membrane : a novel target for viral and bacterial pathogens
Author(s) Hawkes, David J.
Mak, JohnsonORCID iD for Mak, Johnson
Journal name Current drug target
Volume number 7
Issue number 12
Start page 1615
End page 1621
Total pages 8
Publisher Bentham Science Publishers
Place of publication Bussum, Netherlands
Publication date 2006-12
ISSN 1389-4501
Keyword(s) lipid rafts
Summary Abstracts: Lipid rafts are defined as specialized, dynamic microdomains that can be found in plasma membrane, and they are enriched with cholesterol and sphingolipids. Since lipid rafts’ first debut in the mid 1990’s, their existence, function and biological relevance have been a subject of intense scrutiny within the scientific community. Throughout this debate, we have learned a great deal regarding how cargos (both pathogens and cellular factors) are transported into and out of the cell through raft-dependent or raft-independent pathways. It is now apparent that a number of toxins, bacterial-, and viral-pathogens are able to exploit cholesterol and/or lipid rafts to gain a foot hold in their target hosts. The objective of this review is to describe our current appreciation on how selected pathogens utilise cholesterol and/or lipid rafts to support their propagation and to speculate on how some of these observations can be explored for the development of novel strategies that target plasma membrane lipids to control the spread of these viral- and bacterial-pathogens.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2006, Bentham Science Publishers
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Document type: Journal Article
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School of Medicine
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