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Innate immunity and intracellular trafficking : insights for novel anti-HIV-1 therapeutics

Jones, Kate L. and Mak, Johnson 2005, Innate immunity and intracellular trafficking : insights for novel anti-HIV-1 therapeutics, Current pharmacogenomics and personalized medicine, vol. 3, no. 2, pp. 97-117, doi: 10.2174/1570160054022962.

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Title Innate immunity and intracellular trafficking : insights for novel anti-HIV-1 therapeutics
Author(s) Jones, Kate L.
Mak, JohnsonORCID iD for Mak, Johnson orcid.org/0000-0002-5229-5707
Journal name Current pharmacogenomics and personalized medicine
Volume number 3
Issue number 2
Start page 97
End page 117
Total pages 21
Publisher Bentham Science Publishers
Place of publication Bussum, Netherlands
Publication date 2005-06
ISSN 1875-6913
1875-6921
Keyword(s) vif
apobec
restriction
lv
ref
trim
late domain
vps
mvb
Summary It is now evident that host cells have evolved a remarkable variety of antiretroviral activities to defend themselves against viral invaders and in return viruses have developed ingenious ways to circumvent these defences and, in some cases, actually hijack cellular proteins in order to facilitate their replication. Study of this cat and mouse interplay between viruses and their host cells throughout evolution has lead to the identification of some of the most sophisticated antiviral strategies that mammals have developed to prevent viral infection. Recently, a wave of publications has significantly enhanced our understanding of the relationship between human immunodeficiency virus type 1 (HIV-1) and its host, including: 1) the HIV-1 protein Vif and its interaction with host cell nucleic acid editing enzymes; 2) the host cell restrictive factors that provide protection against retroviral infection, such as TRIM5; and 3) the late domains of retroviruses and their relationship with the host cell vacuolar protein sorting pathway. The focus of this review is to provide an up-to-date account of these important areas of HIV-1 research and highlight how some of these new discoveries can potentially be exploited for the development of novel anti-retroviral therapeutics.
Language eng
DOI 10.2174/1570160054022962
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30047459

Document type: Journal Article
Collection: School of Medicine
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