Too much of a good thing : why it is bad to stimulate the beta cell to secrete insulin

Aston-Mourney, K., Proietto, J., Morahan, G. and Andrikopoulos, S. 2008, Too much of a good thing : why it is bad to stimulate the beta cell to secrete insulin, Diabetologia, vol. 51, no. 4, pp. 540-545, doi: 10.1007/s00125-008-0930-2.

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Title Too much of a good thing : why it is bad to stimulate the beta cell to secrete insulin
Author(s) Aston-Mourney, K.ORCID iD for Aston-Mourney, K.
Proietto, J.
Morahan, G.
Andrikopoulos, S.
Journal name Diabetologia
Volume number 51
Issue number 4
Start page 540
End page 545
Total pages 6
Publisher Springer
Place of publication Heidelberg, Germany
Publication date 2008
ISSN 0012-186X
Keyword(s) C57BL/6
endoplasmic reticulum stress
Islet dysfunction
oxidative stress
Summary In many countries, first- or second-line pharmacological treatment of patients with type 2 diabetes consists of sulfonylureas (such as glibenclamide [known as glyburide in the USA and Canada]), which stimulate the beta cell to secrete insulin. However, emerging evidence suggests that forcing the beta cell to secrete insulin at a time when it is struggling to cope with the demands of obesity and insulin resistance may accelerate its demise. Studies on families with persistent hyperinsulinaemic hypoglycaemia of infancy (PHHI), the primary defect of which is hypersecretion of insulin, have shown that overt diabetes can develop later in life despite normal insulin sensitivity. In addition, in vitro experiments have suggested that reducing insulin secretion from islets isolated from patients with diabetes can restore insulin pulsatility and improve function. This article will explore the hypothesis that forcing the beta cell to hypersecrete insulin may be counterproductive and lead to dysfunction and death via mechanisms that may involve the endoplasmic reticulum and oxidative stress. We suggest that, in diabetes, therapeutic approaches should be targeted towards relieving the demand on the beta cell to secrete insulin.
Language eng
DOI 10.1007/s00125-008-0930-2
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2008, Springer-Verlag
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Document type: Journal Article
Collection: School of Medicine
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