An investigation of the efficacy of a novel ocular lubricant

Dumbleton, Kathy, Woods, Craig and Fonn, Desmond 2009, An investigation of the efficacy of a novel ocular lubricant, Eye and contact lens, vol. 35, no. 3, pp. 149-155, doi: 10.1097/ICL.0b013e3181a2c986.

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Title An investigation of the efficacy of a novel ocular lubricant
Author(s) Dumbleton, Kathy
Woods, CraigORCID iD for Woods, Craig
Fonn, Desmond
Journal name Eye and contact lens
Volume number 35
Issue number 3
Start page 149
End page 155
Total pages 7
Publisher Lippincott Williams & Wilkins
Place of publication Philadelphia, Pa.
Publication date 2009-05
ISSN 1542-233X
Keyword(s) dry eyes
artificial tears
ocular lubricants
dry eye treatment
dry eye symptoms
Summary Objective: To investigate the efficacy of a novel ocular lubricant compared with a commercially marketed ocular lubricant in a group of noncontact lens wearers currently using over-the-counter products for the management of symptoms of moderate to severe dry eye.

Methods: This was a prospective, double-masked study that randomized 110 subjects in a ratio of 1:1 to receive a novel ocular lubricant (test group) or a marketed ocular lubricant (control group). Subjects were instructed to instill the lubricant eye drops at least three times daily. After enrollment, subjects were evaluated at baseline and at 7 and 30 days. They were also required to complete a series of home-based subjective questionnaires after 15 days. Main outcomes were subjective symptoms and objective clinical assessment at 7 and 30 days.

Results: The test group had higher overall comfort ratings than the control group (P = 0.012). Seventy-one percent of the test group and 57% of the control group said the drops used “somewhat” or “definitely” improved ocular comfort; 62% of the test group had greater end-of-day comfort compared with 45% of the control group (P = 0.015). There were no between-group differences in visual acuity, tear quality or quantity, corneal staining, conjunctival staining, or bulbar and limbal conjunctival hyperemia.

Conclusions: The novel ocular lubricant offers equivalent or superior comfort compared with a marketed lubricant eye drop. Objective clinical outcomes were not statistically significantly different between the two groups.
Language eng
DOI 10.1097/ICL.0b013e3181a2c986
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2009, Lippincott Williams & Wilkins
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Document type: Journal Article
Collection: School of Medicine
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