Multipurpose disinfecting solutions and their interactions with a silicone hydrogel lens

Sorbara, Luigina, Peterson, Rachael, Woods, Craig and Fonn, Desmond 2009, Multipurpose disinfecting solutions and their interactions with a silicone hydrogel lens, Eye and contact lens, vol. 35, no. 2, pp. 92-97, doi: 10.1097/ICL.0b013e318199df54.

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Title Multipurpose disinfecting solutions and their interactions with a silicone hydrogel lens
Author(s) Sorbara, Luigina
Peterson, Rachael
Woods, CraigORCID iD for Woods, Craig
Fonn, Desmond
Journal name Eye and contact lens
Volume number 35
Issue number 2
Start page 92
End page 97
Total pages 6
Publisher Lippincott Williams & Wilkins
Place of publication Philadelphia, Pa.
Publication date 2009-03
ISSN 1542-233X
Keyword(s) corneal staining
contact lens
silicone hydrogel
care regimen
Summary Purpose: To assess the compatibility of a new silicone hydrogel lens, asmofilcon A (with four multipurpose disinfecting solutions: OPTIFREE RepleniSH, ReNu MultiPlus, Solo-Care Aqua and MeniCare Soft). Ocular responses and subjective responses were monitored with each lens-care system combination.

Methods: The study was conducted as a prospective, bilateral, clinical trial with a single-masked investigator, and randomized cross-over design with four phases, (one for each care system). Each study phase comprised of two consecutive days of lens wear where the lenses were inserted on day 1 directly from the blister-packs and worn for over 8 hr, then inserted on day 2 after overnight disinfection with one of the study lens care systems. Twenty-five adapted soft contact lens wearers who were able to wear their habitual lenses comfortably for more than 12 hr were recruited.

Results: There were statistically significant differences in corneal staining found for all the lens-care systems when comparing the results of day 1 (from the blister pack) with day 2 (following care system use) (P < 0.05). ReNu MultiPlus solution had the highest grade for corneal staining at the 2-hr time point on day 2 which then decreased by 6 hr (P < 0.05). There was no difference between the lens care systems and the rating of subjective comfort over either of the two days. The rating of dryness and burning sensations were only slightly increased at 6 hr for all lens care systems except ReNu MultiPlus where burning was highest on insertion (P < 0.05).

Conclusion: Corneal staining observed in this study does not seem to have been related to the presence of polyhexamethylene biguanide (0.0001% wv) that was present in three of the four care systems. Only one care system (ReNu MultiPlus) demonstrated an associated level of corneal staining that was statistically significant; however, this was not considered to be of clinical relevance. These results suggest that using this novel surface-treated silicone hydrogel lens may result in less lens and lens care-related interactions.
Language eng
DOI 10.1097/ICL.0b013e318199df54
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2009, Lippincott Williams & Wilkins
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Document type: Journal Article
Collection: School of Medicine
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