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Lipid rafts and HIV-1 : from viral entry to assembly of progeny virions

Campbell, S. M., Crowe, S. M. and Mak, J. 2001, Lipid rafts and HIV-1 : from viral entry to assembly of progeny virions, Journal of clinical virology, vol. 22, no. 3, pp. 217-227, doi: 10.1016/S1386-6532(01)00193-7.

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Title Lipid rafts and HIV-1 : from viral entry to assembly of progeny virions
Author(s) Campbell, S. M.
Crowe, S. M.
Mak, J.ORCID iD for Mak, J. orcid.org/0000-0002-5229-5707
Journal name Journal of clinical virology
Volume number 22
Issue number 3
Start page 217
End page 227
Total pages 11
Publisher Elsevier BV
Place of publication Amsterdam, The Netherlands
Publication date 2001-10
ISSN 1386-6532
1873-5967
Keyword(s) lipid rafts
HIV-1
cholesterol
caveolin
Summary Background: Lipid rafts are currently an intensely investigated topic of cell biology. In addition to a demonstrated role in signal transduction of the host cell, lipid rafts serve as entry and exit sites for microbial pathogens and toxins, such as FimH-expressing enterobacteria, influenza virus, measles virus and cholera toxin. Furthermore, caveolae, a specialised form of lipid raft, are required for the conversion of the non-pathogenic prion protein to the pathogenic scrapie isoform.

Objectives: A number of reports have shown, directly or indirectly, that lipid rafts are important at various stages of the human immunodeficiency virus type-1 (HIV-1) replication cycle. The purpose of this paper is to provide a brief overview of the role of membrane-associated lipid rafts in cell biology, and to evaluate how HIV-1 has hijacked this cellular component to support HIV-1 replication. Special sections are devoted to discussing the role of lipid rafts in (1) the entry of HIV-1, (2) signal transduction regulation in HIV-1-infected cells, (3) the trafficking of HIV-1 proteins via lipid rafts during HIV-1 assembly; and a further section discusses the role of cholesterol in mature HIV-1.

Summary:
Like a number of other pathogens, HIV-1 has evolved to rely on the host cell lipid rafts to support its propagation during multiple stages of the HIV-1 replication cycle. This review has highlighted the importance of lipid rafts in HIV-1 replication.
Language eng
DOI 10.1016/S1386-6532(01)00193-7
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2001, Elsevier Science B.V.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30047510

Document type: Journal Article
Collection: School of Medicine
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