Lipid rafts and HIV-1 : from viral entry to assembly of progeny virions

Campbell, S. M., Crowe, S. M. and Mak, J. 2001, Lipid rafts and HIV-1 : from viral entry to assembly of progeny virions, Journal of clinical virology, vol. 22, no. 3, pp. 217-227, doi: 10.1016/S1386-6532(01)00193-7.

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Title Lipid rafts and HIV-1 : from viral entry to assembly of progeny virions
Author(s) Campbell, S. M.
Crowe, S. M.
Mak, J.ORCID iD for Mak, J.
Journal name Journal of clinical virology
Volume number 22
Issue number 3
Start page 217
End page 227
Total pages 11
Publisher Elsevier BV
Place of publication Amsterdam, The Netherlands
Publication date 2001-10
ISSN 1386-6532
Keyword(s) lipid rafts
Summary Background: Lipid rafts are currently an intensely investigated topic of cell biology. In addition to a demonstrated role in signal transduction of the host cell, lipid rafts serve as entry and exit sites for microbial pathogens and toxins, such as FimH-expressing enterobacteria, influenza virus, measles virus and cholera toxin. Furthermore, caveolae, a specialised form of lipid raft, are required for the conversion of the non-pathogenic prion protein to the pathogenic scrapie isoform.

Objectives: A number of reports have shown, directly or indirectly, that lipid rafts are important at various stages of the human immunodeficiency virus type-1 (HIV-1) replication cycle. The purpose of this paper is to provide a brief overview of the role of membrane-associated lipid rafts in cell biology, and to evaluate how HIV-1 has hijacked this cellular component to support HIV-1 replication. Special sections are devoted to discussing the role of lipid rafts in (1) the entry of HIV-1, (2) signal transduction regulation in HIV-1-infected cells, (3) the trafficking of HIV-1 proteins via lipid rafts during HIV-1 assembly; and a further section discusses the role of cholesterol in mature HIV-1.

Like a number of other pathogens, HIV-1 has evolved to rely on the host cell lipid rafts to support its propagation during multiple stages of the HIV-1 replication cycle. This review has highlighted the importance of lipid rafts in HIV-1 replication.
Language eng
DOI 10.1016/S1386-6532(01)00193-7
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2001, Elsevier Science B.V.
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Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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