Granulocyte-macrophage colony-stimulating factor augments phagocytosis of mycobacterium avium complex by human immunodeficiency virus type 1-infected monocytes/macrophages in vitro and in vivo

Granulocyte-macrophage colony-stimulating factor augments phagocytosis of mycobacterium avium complex by human immunodeficiency virus type 1-infected monocytes/macrophages in vitro and in vivo

Kedzierska, Katherine, Mak, Johnson, Mijch, Anne, Cooke, Ian, Rainbird, Melissa, Roberts, Sally, Paukovics, Geza, Jolley, Damien, Lopez, Angel and Crowe, Suzanne M. 2000, Granulocyte-macrophage colony-stimulating factor augments phagocytosis of mycobacterium avium complex by human immunodeficiency virus type 1-infected monocytes/macrophages in vitro and in vivo, Journal of infectious diseases, vol. 181, no. 1, pp. 390-394.

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Title	Granulocyte-macrophage colony-stimulating factor augments phagocytosis of mycobacterium avium complex by human immunodeficiency virus type 1-infected monocytes/macrophages in vitro and in vivo
Author(s)	Kedzierska, Katherine Mak, Johnson Mijch, Anne Cooke, Ian Rainbird, Melissa Roberts, Sally Paukovics, Geza Jolley, Damien Lopez, Angel Crowe, Suzanne M.
Journal name	Journal of infectious diseases
Volume number	181
Issue number	1
Start page	390
End page	394
Total pages	5
Publisher	Oxford University Press
Place of publication	Cary, N. C.
Publication date	2000
ISSN	0022-1899 1537-6613
Keyword(s)	cultured cells granulocyte-macrophage colony-stimulating factor HIV infections HIV-1 macrophages monocytes mycobacterium avium complex mycobacterium avium-intracellulare Infection phagocytosis
Summary	The role of human immunodeficiency virus type 1 (HIV-1) infection on the ability of human monocytes/macrophages to phagocytose Mycobacterium avium complex (MAC) in vivo and in vitro and the effect of granulocyte-macrophage colony-stimulating factor (GM-CSF) on this function were investigated. By use of a flow cytometric assay to quantify phagocytosis, HIV-1 infection was found to impair the ability of monocyte-derived macrophages to phagocytose MAC in vitro, whereas GM-CSF significantly improved this defect. Phagocytosis was not altered by exposure to a mutant form of GM-CSF (E21R) binding only to the α chain of the GM-CSF receptor, suggesting that signaling by GM-CSF that leads to augmentation of phagocytosis is via the β chain of the receptor. In a patient with AIDS and disseminated multidrug-resistant MAC infection, GM-CSF treatment improved phagocytosis of MAC by peripheral blood monocytes and reduced bacteremia. These results imply that GM-CSF therapy may be useful in restoring antimycobacterial function by human monocytes/macrophages.
Language	eng
Field of Research	119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective	970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category	C1.1 Refereed article in a scholarly journal
Copyright notice	©2000, Infectious Diseases Society of America
Persistent URL	http://hdl.handle.net/10536/DRO/DU:30047514

Document type:	Journal Article
Collection:	School of Medicine

Citation counts:	Cited 45 times in TR Web of Science Cited 48 times in Scopus
Access Statistics:	14 Abstract Views, 1 File Downloads - Detailed Statistics
Created:	Thu, 30 Aug 2012, 09:38:05 EST

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Granulocyte-macrophage colony-stimulating factor augments phagocytosis of mycobacterium avium complex by human immunodeficiency virus type 1-infected monocytes/macrophages in vitro and in vivo

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