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Early events of HIV-1 infection : can signalling be the next therapeutic target?

Jones, Kate L., Smyth, Redmond P., Pereira, Candida F., Cameron, Paul U., Lewin, Sharon R., Jaworowski, Anthony and Mak, Johnson 2011, Early events of HIV-1 infection : can signalling be the next therapeutic target?, Journal of neuroimmune pharmacology, vol. 6, no. 2, pp. 269-283, doi: 10.1007/s11481-011-9268-5.

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Title Early events of HIV-1 infection : can signalling be the next therapeutic target?
Author(s) Jones, Kate L.
Smyth, Redmond P.
Pereira, Candida F.
Cameron, Paul U.
Lewin, Sharon R.
Jaworowski, Anthony
Mak, JohnsonORCID iD for Mak, Johnson orcid.org/0000-0002-5229-5707
Journal name Journal of neuroimmune pharmacology
Volume number 6
Issue number 2
Start page 269
End page 283
Total pages 15
Publisher Springer New York LLC
Place of publication New York, N. Y.
Publication date 2011-06
ISSN 1557-1890
1557-1904
Keyword(s) HIV-1
signaling
trafficking
cytoskeleton
uncoating
latency
chemokine coreceptor
entry
virological synapse
Summary Intracellular signaling events are signposts of biological processes, which govern the direction and action of biological activities. Through millions of years of evolution, pathogens, such as viruses, have evolved to hijack host cell machinery to infect their targets and are therefore dependent on host cell signaling for replication. This review will detail our current understanding of the signaling events that are important for the early steps of HIV-1 replication. More specifically, the therapeutic potential of signaling events associated with chemokine coreceptors, virus entry, viral synapses, and post-entry processes will be discussed. We argue that these pathways may represent novel targets for antiviral therapy.
Language eng
DOI 10.1007/s11481-011-9268-5
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2011, Springer
Persistent URL http://hdl.handle.net/10536/DRO/DU:30047518

Document type: Journal Article
Collection: School of Medicine
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Created: Thu, 30 Aug 2012, 09:38:25 EST

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