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Increased plasma peroxides as a marker of oxidative stress in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)

Maes, Michael, Kubera, Marta, Uytterhoeven, Marc, Vrydags, Nicolas and Bosmans, Eugene 2011, Increased plasma peroxides as a marker of oxidative stress in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), Medical science monitor, vol. 17, no. 4, pp. SC11-SC15.

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Title Increased plasma peroxides as a marker of oxidative stress in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)
Author(s) Maes, Michael
Kubera, Marta
Uytterhoeven, Marc
Vrydags, Nicolas
Bosmans, Eugene
Journal name Medical science monitor
Volume number 17
Issue number 4
Start page SC11
End page SC15
Total pages 5
Publisher Medical Science International
Place of publication Warsaw, Poland
Publication date 2011
ISSN 1234-1010
1643-3750
Keyword(s) antioxidantsas a marker of oxidative stress
CFS
chronic fatigue syndrome
inflammation
myalgic encephalomyelitis
oxidative stress
Summary Background: There is evidence that myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterized by activation of immune, inflammatory, oxidative and nitrosative stress (IO&NS) pathways. The present study was carried out in order to examine whether ME/CFS is accompanied by increased levels of plasma peroxides and serum oxidized LDL (oxLDL) antibodies, two biomarkers of oxidative stress.

Material/Methods: Blood was collected from 56 patients with ME/CFS and 37 normal volunteers. Severity of ME/CFS was measured using the Fibromyalgia and Chronic Fatigue Syndrome (FF) Rating Scale.

Results: Plasma peroxide concentrations were significantly higher in patients with ME/CFS than in normal controls. There was a trend towards significantly higher serum oxLDL antibodies in ME/CFS than in controls. Both biomarkers contributed significantly in discriminating between patients with ME/CFS and normal controls. Plasma peroxide and serum oxLDL antibody levels were both significantly related to one of the FF symptoms.

Conclusions: The results show that ME/CFS is characterized by increased oxidative stress.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2011, Med Sci Monit
Persistent URL http://hdl.handle.net/10536/DRO/DU:30047546

Document type: Journal Article
Collection: School of Medicine
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