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IgM-mediated autoimmune responses directed against anchorage epitopes are greater in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) than in major depression

Maes, Michael, Mihaylova, Ivana, Kubera, Marta, Leunis, Jean-Claude, Twisk, Frank N. M. and Geffard, Michel 2012, IgM-mediated autoimmune responses directed against anchorage epitopes are greater in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) than in major depression, Metabolic brain disease, vol. 27, no. 4, pp. 415-423, doi: 10.1007/s11011-012-9316-8.

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Title IgM-mediated autoimmune responses directed against anchorage epitopes are greater in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) than in major depression
Author(s) Maes, Michael
Mihaylova, Ivana
Kubera, Marta
Leunis, Jean-Claude
Twisk, Frank N. M.
Geffard, Michel
Journal name Metabolic brain disease
Volume number 27
Issue number 4
Start page 415
End page 423
Total pages 9
Publisher Springer New York LLC
Place of publication New York, N. Y.
Publication date 2012-12
ISSN 0885-7490
1573-7365
Keyword(s) depression
chronic fatigue syndrome
physio-somatic symptoms
oxidative and nitrosative stress
inflammation
cytokines
autoimmunity
Summary Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and depression are considered to be neuro-immune disorders (Maes and Twisk, BMC Medicine 8:35, 2010). There is also evidence that depression and ME/CFS are accompanied by oxidative and nitrosative stress (O&NS) and by increased autoantibodies to a number of self-epitopes some of which have become immunogenic due to damage by O&NS. The aim of this study is to examine IgM-mediated autoimmune responses to different self-epitopes in ME/CFS versus depression. We examined serum IgM antibodies to three anchorage molecules (palmitic and myristic acid and S-farnesyl-L-cysteine); acetylcholine; and conjugated NO-modified adducts in 26 patients with major depression; 16 patients with ME/CFS, 15 with chronic fatigue; and 17 normal controls. Severity of fatigue and physio-somatic (F&S) symptoms was measured with the Fibromyalgia and Chronic Fatigue Syndrome Rating Scale. Serum IgM antibodies to the three anchorage molecules and NO-phenylalanine were significantly higher in ME/CFS than in depression. The autoimmune responses to oxidatively, but not nitrosatively, modified self-epitopes were significantly higher in ME/CFS than in depression and were associated with F&S symptoms. The autoimmune activity directed against conjugated acetylcholine did not differ significantly between ME/CFS and depression, but was greater in the patients than controls. Partially overlapping pathways, i.e. increased IgM antibodies to a multitude of neo-epitopes, underpin both ME/CFS and depression, while greater autoimmune responses directed against anchorage molecules and oxidatively modified neo-epitopes discriminate patients with ME/CFS from those with depression. These autoimmune responses directed against neoantigenic determinants may play a role in the dysregulation of key cellular functions in both disorders, e.g. intracellular signal transduction, cellular differentiation and apoptosis, but their impact may be more important in ME/CFS than in depression.
Language eng
DOI 10.1007/s11011-012-9316-8
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2012, Springer Science+Business Media, LLC
Persistent URL http://hdl.handle.net/10536/DRO/DU:30047549

Document type: Journal Article
Collection: School of Medicine
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