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Malondialdehyde plasma concentration correlates with declarative and working memory in patients with recurrent depressive disorder

Talarowska, Monika, Galecki, Piotr, Maes, Michael, Gardner, Ann, Chamielec, Marcelina, Orzechowska, Agata, Bobinska, Kinga and Kowalczyk, Edward 2012, Malondialdehyde plasma concentration correlates with declarative and working memory in patients with recurrent depressive disorder, Molecular biology reports, vol. 39, no. 5, pp. 5359-5366, doi: 10.1007/s11033-011-1335-8.

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Title Malondialdehyde plasma concentration correlates with declarative and working memory in patients with recurrent depressive disorder
Author(s) Talarowska, Monika
Galecki, Piotr
Maes, Michael
Gardner, Ann
Chamielec, Marcelina
Orzechowska, Agata
Bobinska, Kinga
Kowalczyk, Edward
Journal name Molecular biology reports
Volume number 39
Issue number 5
Start page 5359
End page 5366
Total pages 8
Publisher Springer Netherlands
Place of publication Dordrecht, The Netherlands
Publication date 2012-05
ISSN 0301-4851
1573-4978
Keyword(s) oxidative stress
MDA
depressive disorders
cognitive functions
Summary Oxidative stress has been implicated in the cognitive decline, especially in memory impairment. The purpose of this study was to determine the concentration of malondialdehyde (MDA) in patients with recurrent depressive disorders (rDD) and to define relationship between plasma levels of MDA and the cognitive performance. The study comprised 46 patients meeting criteria for rDD. Cognitive function assessment was based on: The Trail Making Test , The Stroop Test, Verbal Fluency Test and Auditory-Verbal Learning Test. The severity of depression symptoms was assessed using the Hamilton Depression Rating Scale (HDRS). Statistically significant differences were found in the intensity of depression symptoms, measured by the HDRS on therapy onset versus the examination results after 8 weeks of treatment (P < 0.001). Considering the 8-week pharmacotherapy period, rDD patients presented better outcomes in cognitive function tests. There was no statistically significant correlation between plasma MDA levels, and the age, disease duration, number of previous depressive episodes and the results in HDRS applied on admission and on discharge. Elevated levels of MDA adversely affected the efficiency of visual-spatial and auditory-verbal working memory, short-term declarative memory and the delayed recall declarative memory. 1. Higher concentration of plasma MDA in rDD patients is associated with the severity of depressive symptoms, both at the beginning of antidepressants pharmacotherapy, and after 8 weeks of its duration. 2. Elevated levels of plasma MDA are related to the impairment of visual-spatial and auditory-verbal working memory and short-term and delayed declarative memory.
Language eng
DOI 10.1007/s11033-011-1335-8
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2011, Springer Science+Business Media B.V.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30047552

Document type: Journal Article
Collection: School of Medicine
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Created: Thu, 30 Aug 2012, 09:42:15 EST

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