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Dimerization of retroviral RNA genomes : an inseparable pair

Paillart, Jean-Christophe, Shehu-Xhilaga, Miranda, Marquet, Roland and Mak, Johnson 2004, Dimerization of retroviral RNA genomes : an inseparable pair, Nature reviews. Microbiology, vol. 2, no. 6, pp. 461-472, doi: 10.1038/nrmicro903.

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Title Dimerization of retroviral RNA genomes : an inseparable pair
Author(s) Paillart, Jean-Christophe
Shehu-Xhilaga, Miranda
Marquet, Roland
Mak, JohnsonORCID iD for Mak, Johnson orcid.org/0000-0002-5229-5707
Journal name Nature reviews. Microbiology
Volume number 2
Issue number 6
Start page 461
End page 472
Total pages 12
Publisher Nature Publishing Group
Place of publication London, England
Publication date 2004-06
ISSN 1740-1526
1740-1534
Keyword(s) base sequence
dimerization
genome
viral
HIV-1
models
molecular
molecular sequence data
nucleic acid conformation
virus replication
Summary Many viruses carry more than one segment of nucleic acid into the virion particle, but retroviruses are the only known group of viruses that contain two identical (or nearly identical) copies of the RNA genome within the virion. These RNA genomes are non-covalently joined together through a process known as genomic RNA dimerization. Uniquely, the RNA dimerization of the retroviral genome is of crucial importance for efficient retroviral replication. In this article, our current understanding of the relationship between retroviral genome conformation, dimerization and replication is reviewed.
Language eng
DOI 10.1038/nrmicro903
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2004, Nature Publishing Group
Persistent URL http://hdl.handle.net/10536/DRO/DU:30047554

Document type: Journal Article
Collection: School of Medicine
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