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Inhibitory effect of antidepressant drugs on contact hypersensitivity reaction

Kubera, Marta, Curzytek, Katarzyna, Majewska-Szczepanik, Monika, Szczepanik, Marian, Marcinska, Katarzyna, Ptak, Wlodzimierz, Leskiewicz, Monica, Maes, Michael, Basta-Kaim, Agnieszka, Budziszewska, Boguslawa, Detka, Jan, Duda, Weronika and Lason, Wladyslaw 2012, Inhibitory effect of antidepressant drugs on contact hypersensitivity reaction, Pharmacological reports, vol. 64, no. 3, pp. 714-722.

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Title Inhibitory effect of antidepressant drugs on contact hypersensitivity reaction
Author(s) Kubera, Marta
Curzytek, Katarzyna
Majewska-Szczepanik, Monika
Szczepanik, Marian
Marcinska, Katarzyna
Ptak, Wlodzimierz
Leskiewicz, Monica
Maes, Michael
Basta-Kaim, Agnieszka
Budziszewska, Boguslawa
Detka, Jan
Duda, Weronika
Lason, Wladyslaw
Journal name Pharmacological reports
Volume number 64
Issue number 3
Start page 714
End page 722
Total pages 9
Publisher Polska Akademia Nauk, Instytut Farmakologii
Place of publication Krakow, Poland
Publication date 2012
ISSN 1734-1140
Keyword(s) contact hypersensitivity
desipramine
fluoxetine
interleukin 10
Summary Background: Contact hypersensitivity (CS) reaction in the skin is T-cell mediated immune reaction which plays a major role in the pathogenesis and chronicity of various inflammatory skin disorders and, like other delayed-type hypersensitivity (DTH) reactions, affords immunity against tumor cells and microbes. CS response is a self-limiting reaction, and interleukin (IL)-10 is considered to be a natural suppressant of cutaneous inflammatory response. Recently, it has been demonstrated that major depression is related to activation of the inflammatory response and elevation of some parameters of cell-mediated immunity. It has been suggested that such activation of the immune system may play a role in etiology of depression. If this immunoactivation is involved in etiology of depression, one would expect that antidepressant agents may have negative immunoregulatory effects. To the best of our knowledge, the effect of antidepressants on contact hypersensitivity has not been studied.

Methods: The aim of the present study was to establish the effect of prolonged desipramine or fluoxetine treatment on CS reaction to picryl chloride.

Results: Antidepressants significantly suppressed CS reaction, fluoxetine by 53% whereas desipramine by 47% compared to positive control. Moreover, desipramine and fluoxetine decreased relative weight of auxillary lymph nodes. Desipramine decreased also relative weight of inguinal lymph nodes and spleens whereas desipramine and fluoxetine increased production of IL-10 in comparison to positive control.

Conclusion: The observed effect of antidepressant drugs on CS reaction is consistent with the hypothesis that T-cell mediated immunity is targeted by antidepressants.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2012, by Institute of Pharmacology, Polish Academy of Sciences
Persistent URL http://hdl.handle.net/10536/DRO/DU:30047589

Document type: Journal Article
Collection: School of Medicine
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