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Human brain structural change related to acute single exposure to sarin

Yamasue, Hidenori, Abe, Osamu, Kasai, Kiyoto, Suga, Motomu, Iwanami, Akira, Yamada, Haruyasu, Tochigi, Mamoru, Ohtani, Toshiyuki, Rogers, Mark A., Sasaki, Tsukasa, Aoki, Shigeki, Kato, Tadafumi and Kato, Nobumasa 2007, Human brain structural change related to acute single exposure to sarin, Annals of neurology, vol. 61, no. 1, pp. 37-46, doi: 10.1002/ana.21024.

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Title Human brain structural change related to acute single exposure to sarin
Author(s) Yamasue, Hidenori
Abe, Osamu
Kasai, Kiyoto
Suga, Motomu
Iwanami, Akira
Yamada, Haruyasu
Tochigi, Mamoru
Ohtani, Toshiyuki
Rogers, Mark A.ORCID iD for Rogers, Mark A. orcid.org/0000-0002-6808-9545
Sasaki, Tsukasa
Aoki, Shigeki
Kato, Tadafumi
Kato, Nobumasa
Journal name Annals of neurology
Volume number 61
Issue number 1
Start page 37
End page 46
Total pages 10
Publisher John Wiley & Sons
Place of publication Hoboken, N. J.
Publication date 2007-01
ISSN 0364-5134
1531-8249
Keyword(s) cholinesterase
organophosphate
sarin
Summary Objective This study aimed to identify persistent morphological changes subsequent to an acute single-time exposure to sarin, a highly poisonous organophosphate, and the neurobiological basis of long-lasting somatic and cognitive symptoms in victims exposed to sarin.

Methods Thirty-eight victims of the 1995 Tokyo subway sarin attack, all of whom had been treated in an emergency department for sarin intoxication, and 76 matched healthy control subjects underwent T1-weighted and diffusion tensor magnetic resonance imaging (DTI) in 2000 to 2001. Serum cholinesterase (ChE) levels measured immediately and longitudinally after the exposure and the current severity of chronic reports in the victims were also evaluated.

Results The voxel-based morphometry exhibited smaller than normal regional brain volumes in the insular cortex and neighboring white matter, as well as in the hippocampus in the victims. The reduced regional white matter volume correlated with decreased serum cholinesterase levels and with the severity of chronic somatic complaints related to interoceptive awareness. Voxel-based analysis of diffusion tensor magnetic resonance imaging further demonstrated an extensively lower than normal fractional anisotropy in the victims. All these findings were statistically significant (corrected p < 0.05).

Interpretation Sarin intoxication might be associated with structural changes in specific regions of the human brain, including those surrounding the insular cortex, which might be related to elevated subjective awareness of internal bodily status in exposed individuals.
Language eng
DOI 10.1002/ana.21024
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2006, American Neurological Association
Persistent URL http://hdl.handle.net/10536/DRO/DU:30047615

Document type: Journal Article
Collection: School of Psychology
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